(Q35683272)

26147105

9 August 2017

title

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia (English)

1 reference

9 August 2017

1 reference

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147105%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

William N Pappano

1

1 reference

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14 June 2020

Jun Guo

2

1 reference

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14 June 2020

Yupeng He

3

1 reference

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14 June 2020

Debra Ferguson

4

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14 June 2020

Sujatha Jagadeeswaran

5

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14 June 2020

Donald J Osterling

6

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14 June 2020

Wenqing Gao

7

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14 June 2020

Julie K Spence

8

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14 June 2020

Marina Pliushchev

9

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14 June 2020

Ramzi F Sweis

10

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14 June 2020

Fritz G Buchanan

11

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14 June 2020

Michael R Michaelides

12

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14 June 2020

Alexander R Shoemaker

13

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14 June 2020

Chris Tse

14

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14 June 2020

language of work or name

English

0 references

publication date

6 July 2015

1 reference

9 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147105%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

volume

10

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14 June 2020

issue

7

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14 June 2020

page(s)

e0131716

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Creative Commons Attribution 4.0 International

14 June 2020

copyright license

start time

6 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

1 reference

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The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

12 July 2018

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Chromatin proteins and modifications as drug targets

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Epigenetic regulation of autophagy by the methyltransferase G9a

12 July 2018

1 reference

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

12 July 2018

1 reference

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Epigenetic protein families: a new frontier for drug discovery

12 July 2018

1 reference

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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

12 July 2018

1 reference

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

12 July 2018

1 reference

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Histone lysine methylation and demethylation pathways in cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Epigenetic modifications and human disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

G9a and Glp methylate lysine 373 in the tumor suppressor p53

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Protein methyltransferases as a target class for drug discovery

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Differentiation therapy of leukemia: 3 decades of development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

High-resolution profiling of histone methylations in the human genome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

All trans retinoic acid in acute promyelocytic leukemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells

12 July 2018

1 reference

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DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

The epigenetic magic of histone lysine methylation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492996

10.1371/JOURNAL.PONE.0131716

25 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147105%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147105%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

26147105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147105%20AND%20SRC:MED&resulttype=core&format=json