(Q35683577)

9 August 2017

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title

4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies (English)

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natural product chemistry

9 August 2017

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1 reference

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Karl-Heinz Altmann

1

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9 August 2017

Andreas Flörsheimer

series ordinal

2

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9 August 2017

Terence O'Reilly

series ordinal

3

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9 August 2017

Markus Wartmann

series ordinal

4

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9 August 2017

language of work or name

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1 January 2004

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Progress in medicinal chemistry

9 August 2017

published in

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9 August 2017

volume

42

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9 August 2017

page(s)

171-205

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THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

9 August 2017

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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies

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Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

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Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

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Recent developments in the chemistry, biology and medicine of the epothilones

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Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C.

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Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones

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Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation

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Epothilone B and its analogs - a new family of anticancer agents

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En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B

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A common pharmacophore for cytotoxic natural products that stabilize microtubules

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Structure of the alpha beta tubulin dimer by electron crystallography

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Resistance to antimitotic agents as genetic probes of microtubule structure and function

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7 January 2021

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

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7 January 2021

Synthesis of epothilones A and B in solid and solution phase

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7 January 2021

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells

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Synthesis, structure proof, and biological activity of epothilone cyclopropanes

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Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

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7 January 2021

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

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Synthesis and biological activity of novel epothilone aziridines

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7 January 2021

Derivatization of the C12-C13 functional groups of epothilones A, B and C

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7 January 2021

An Efficient Asymmetric Epoxidation Method fortrans-Olefins Mediated by a Fructose-Derived Ketone

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7 January 2021

A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus

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7 January 2021

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

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7 January 2021

Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series

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7 January 2021

On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings

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7 January 2021

Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

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Generation of novel epothilone analogs with cytotoxic activity by biotransformation

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7 January 2021

Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D.

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7 January 2021

The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

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7 January 2021

On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones

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7 January 2021

Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy

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7 January 2021

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Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues

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7 January 2021

Synthesis and biological evaluation of highly potent analogues of epothilones B and D.

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7 January 2021

Dioxiranes: synthesis and reactions of methyldioxiranes

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7 January 2021

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

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7 January 2021

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

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7 January 2021

Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21

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7 January 2021

Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B.

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7 January 2021

Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts

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7 January 2021

10.1016/S0079-6468(04)42004-9

Identifiers

DOI

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