(Q35794586)

10 August 2017

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title

In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology (English)

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10 August 2017

1

David M Holtzman

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10 August 2017

1 January 2004

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Journal of Molecular Neuroscience

10 August 2017

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10 August 2017

23

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10 August 2017

247-254

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10 August 2017

3

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https://scigraph.springernature.com/pub.10.1385/jmn:23:3:247

10 August 2017

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cites work

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12 December 2020

Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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Apolipoprotein J and Alzheimer's amyloid beta solubility

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat.

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12 December 2020

Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta

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12 December 2020

Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

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Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

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Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging.

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

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12 December 2020

Apolipoprotein E and Alzheimer's disease

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing

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12 December 2020

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

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Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.

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12 December 2020

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

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12 December 2020

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

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A prospective study of Alzheimer disease in Down syndrome.

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Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

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Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

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12 December 2020

Apolipoproteins in human cerebrospinal fluid

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Apolipoprotein J (clusterin) and Alzheimer's disease

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Nascent astrocyte particles differ from lipoproteins in CSF.

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Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice.

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12 December 2020

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

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Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease.

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12 December 2020

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

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12 December 2020

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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12 December 2020

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

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12 December 2020

PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures

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12 December 2020

Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice

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12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

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12 December 2020

Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy

1 reference

12 December 2020

Identifiers

DOI

10.1385/JMN:23:3:247

1 reference

PubMed ID

15181253

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15181253