(Q35801427)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

2

1 reference

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26 February 2020

Lee B Meakin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Peter J Delisser

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Sara Windahl

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

author name string

Henry Todd

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Lance E Lanyon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Joanna S Price

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

language of work or name

English

0 references

publication date

9 October 2015

1 reference

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26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

page(s)

e0140260

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

26 February 2020

copyright license

start time

9 October 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

1 reference

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Planar cell polarity aligns osteoblast division in response to substrate strain

27 July 2018

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Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.

27 July 2018

1 reference

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Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.

27 July 2018

1 reference

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27 July 2018

1 reference

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The role of estrogen and androgen receptors in bone health and disease

27 July 2018

1 reference

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The role of estrogen receptor α in the regulation of bone and growth plate cartilage.

27 July 2018

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WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta

27 July 2018

1 reference

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Mutations in WNT1 cause different forms of bone fragility

27 July 2018

1 reference

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WNT signaling in bone homeostasis and disease: from human mutations to treatments

27 July 2018

1 reference

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Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Estrogen receptors α and β have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

27 July 2018

1 reference

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Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice

27 July 2018

1 reference

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PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification

27 July 2018

1 reference

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Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Effects of age and gender on WNT gene expression in human bone marrow stromal cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Reduced bone formation and increased bone resorption: rational targets for the treatment of osteoporosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

27 July 2018

1 reference

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Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Role of WNT16 in the regulation of periosteal bone formation in female mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

WNT7B promotes bone formation in part through mTORC1.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Variation in the Kozak sequence of WNT16 results in an increased translation and is associated with osteoporosis related parameters

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

c-Jun is required for the specification of joint cell fates

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599960

Bone adaptation requires oestrogen receptor-α

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0140260

Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures

21 January 2018

1 reference

12 December 2020

Disproportional Body Growth in Female Estrogen Receptor-α-Inactivated Mice

1 reference

12 December 2020

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice

1 reference

12 December 2020

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0140260

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

26451596

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26451596%20AND%20SRC:MED&resulttype=core&format=json