(Q35815791)

10 August 2017

The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5. (English)

1 reference

10 August 2017

Joshua S Waitzman

1

1 reference

10 August 2017

Adam G Larson

2

1 reference

10 August 2017

Jared C Cochran

3

1 reference

10 August 2017

Nariman Naber

4

1 reference

10 August 2017

Roger Cooke

5

1 reference

10 August 2017

F Jon Kull

6

1 reference

10 August 2017

Edward Pate

7

1 reference

10 August 2017

Sarah E Rice

8

1 reference

10 August 2017

language of work or name

English

0 references

publication date

1 December 2011

1 reference

10 August 2017

10

1 reference

inferred from page(s)

published in

Biophysical Journal

1 reference

10 August 2017

101

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10 August 2017

11

1 reference

10 August 2017

2760-2769

1 reference

describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3297777/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Multiple conformations of the nucleotide site of Kinesin family motors in the triphosphate state

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Loop L5 acts as a conformational latch in the mitotic kinesin Eg5

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Mechanism of cooperative behaviour in systems of slow and fast molecular motors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

9-Angström structure of a microtubule-bound mitotic motor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

The beginning of kinesin's force-generating cycle visualized at 9-A resolution

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Pathway of ATP hydrolysis by monomeric kinesin Eg5

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Allosteric inhibition of kinesin-5 modulates its processive directional motility.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

A structural model for monastrol inhibition of dimeric kinesin Eg5.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Robust colorimetric assays for dynamin's basal and stimulated GTPase activities.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Microtubule-kinesin interface mutants reveal a site critical for communication

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Inhibition of a mitotic motor protein: where, how, and conformational consequences

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

A structural change in the kinesin motor protein that drives motility

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Direct observation of single kinesin molecules moving along microtubules

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Orientation of spin-labeled nucleotides bound to myosin in glycerinated muscle fibers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Analysis of the interaction of the Eg5 Loop5 with the nucleotide site

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

A pathway of structural changes produced by monastrol binding to Eg5.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Docking and rolling, a model of how the mitotic motor Eg5 works

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Mechanistic analysis of the mitotic kinesin Eg5.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Closing of the Nucleotide Pocket of Kinesin-Family Motors upon Binding to Microtubules

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

ATP reorients the neck linker of kinesin in two sequential steps

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297777

Highly processive microtubule-stimulated ATP hydrolysis by dimeric kinesin head domains

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22261065

12 December 2020

inferred from PubMed ID database lookup

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22261065

12 December 2020

inferred from PubMed ID database lookup

Interacting head mechanism of microtubule-kinesin ATPase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22261065

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.BPJ.2011.10.032

1 reference

10 August 2017

1 reference

10 August 2017

1 reference