(Q24598085)

2

0 references

Jing Liu

3

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Sunyoung Kim

4

0 references

Edward J Wojcik

Journal of Biological Chemistry

5

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language of work or name

English

0 references

publication date

25 February 2011

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published in

0 references

volume

286

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issue

8

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page(s)

6201-10

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cites work

The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5

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Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core

24 March 2017

1 reference

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ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism

24 March 2017

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NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site

24 March 2017

1 reference

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Pathway of ATP hydrolysis by monomeric kinesin Eg5

24 March 2017

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ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

24 March 2017

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Three myosin V structures delineate essential features of chemo-mechanical transduction

24 March 2017

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Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

24 March 2017

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The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5

24 March 2017

1 reference

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An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

9-Angström structure of a microtubule-bound mitotic motor

24 March 2017

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24 March 2017

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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

24 March 2017

1 reference

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Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration

24 March 2017

1 reference

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Inhibition of a mitotic motor protein: where, how, and conformational consequences

24 March 2017

1 reference

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Protein sectors: evolutionary units of three-dimensional structure

24 March 2017

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Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

24 March 2017

1 reference

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

24 March 2017

1 reference

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Automated analysis of interatomic contacts in proteins

24 March 2017

1 reference

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Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding

7 April 2017

1 reference

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

27 September 2017

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Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.

27 September 2017

1 reference

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Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein

27 September 2017

1 reference

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Do enthalpy and entropy distinguish first in class from best in class?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Allosteric regulation and catalysis emerge via a common route.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator

27 September 2017

1 reference

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Allosteric modulation of kinases and GPCRs: design principles and structural diversity

27 September 2017

1 reference

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Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

27 September 2017

1 reference

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The origin of protein interactions and allostery in colocalization

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

27 September 2017

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Site-specific incorporation of allosteric-inhibition sites in a protein tyrosine phosphatase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Designing ligands to bind proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

A structural model for monastrol inhibition of dimeric kinesin Eg5.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Entropy-enthalpy compensation: fact or artifact?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Surface sites for engineering allosteric control in proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Monastrol stabilises an attached low-friction mode of Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Ca2+/calmodulin regulation of the Arabidopsis kinesin-like calmodulin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Mechanism of inhibition of human KSP by ispinesib

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

A pathway of structural changes produced by monastrol binding to Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21127071

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heat does not come in different colours: entropy-enthalpy compensation, free energy windows, quantum confinement, pressure perturbation calorimetry, solvation and the multiple causes of heat capacity effects in biomolecular interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21127071