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Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance.
scientific article published in July 2004
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
main subject
glucocorticoid resistance
1 reference
based on heuristic
inferred from title
apoptotic process
1 reference
based on heuristic
inferred from title
author
Johannes Rainer
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
Christian Ploner
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
author name string
S Schmidt
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
E Presul
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
S Riml
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
R Kofler
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
publication date
1 July 2004
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
published in
Cell Death & Differentiation
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
volume
11 Suppl 1
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
page(s)
S45-55
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401456
0 references
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Glucocorticoids in T cell development and function*.
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A conceptual view on glucocorticoid-lnduced apoptosis, cell cycle arrest and glucocorticoid resistance in lymphoblastic leukemia
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Cyclin D3 and c-MYC control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells.
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Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia
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Molecular mechanisms of glucocorticoid action and resistance
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Recent insights into the mechanism of glucocorticosteroid-induced apoptosis
1 reference
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Crossref
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Glucocorticoid-induced apoptosis in lymphocytes
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Glucocorticoid-induced apoptosis in human eosinophils: mechanisms of action
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Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation
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The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors
1 reference
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Crossref
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7 January 2021
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Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival
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7 January 2021
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The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis
1 reference
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7 January 2021
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Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: mechanisms and its clinical impact
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Crossref
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7 January 2021
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Differential control of eosinophil survival by glucocorticoids
1 reference
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Crossref
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7 January 2021
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Rapid glucocorticoid effects on immune cells
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Differential gene expression profile of glucocorticoids, testosterone, and dehydroepiandrosterone in human cells
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7 January 2021
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Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis.
1 reference
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Crossref
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7 January 2021
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Expression profiling of glucocorticoid-treated T-ALL cell lines: rapid repression of multiple genes involved in RNA-, protein- and nucleotide synthesis
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7 January 2021
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Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals
1 reference
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7 January 2021
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Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis
1 reference
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Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays
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reference URL
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7 January 2021
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Glucocorticoid regulation of human eosinophil gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene networks in glucocorticoid-evoked apoptosis of leukemic cells
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Analysis of gene expression patterns during glucocorticoid-induced apoptosis using oligonucleotide arrays
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Crossref
reference URL
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7 January 2021
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Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression
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Classical and novel steroid actions: a unified but complex view
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Correlation of membrane glucocorticoid receptor levels with glucocorticoid-induced apoptotic competence using mutant leukemic and lymphoma cells lines
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Crossref
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inferred from DOI database lookup
Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines
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stated in
Crossref
reference URL
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Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis
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Crossref
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7 January 2021
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inferred from DOI database lookup
Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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inferred from DOI database lookup
Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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inferred from DOI database lookup
Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Glucocorticoids in malignant lymphoid cells: Gene regulation and the minimum receptor fragment for lysis
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.
1 reference
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Crossref
reference URL
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7 January 2021
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1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
1 reference
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reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation
1 reference
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reference URL
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7 January 2021
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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential requirement for caspase 9 in apoptotic pathways in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
1 reference
stated in
Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax-deficient mice with lymphoid hyperplasia and male germ cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 interferes with the execution phase, but not upstream events, in glucocorticoid-induced leukemia apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-talk between glucocorticoid receptor and AP-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondria-dependent apoptosis and cellular pH regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell volume regulation in immune cell apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transactivation assay for determination of glucocorticoid bioactivity in human serum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multidrug resistance in cancer: role of ATP-dependent transporters
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that the beta-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucocorticoid receptor alpha, beta and gamma expression vs in vitro glucocorticod resistance in childhood leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The relationship of blast cell glucocorticoid receptor levels to response to single-agent steroid trial and remission response in children with acute lymphoblastic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucocorticoid-induced apoptosis and treatment sensitivity in acute lymphoblastic leukemia of children
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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Potentiation of dexamethasone-, paclitaxel-, and Ad-p53-induced apoptosis by Bcl-2 antisense oligodeoxynucleotides in drug-resistant multiple myeloma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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Good steroid response in vivo predicts a favorable outcome in children with T-cell acute lymphoblastic leukemia. The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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p53-induced apoptosis in the human T-ALL cell line CCRF-CEM.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
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Thymocyte apoptosis induced by p53-dependent and independent pathways.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
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7 January 2021
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Butyrate-induced reversal of dexamethasone resistance in autonomous rat Nb2 lymphoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
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Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
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Moving disease biology from the lab to the clinic
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401456
retrieved
7 January 2021
based on heuristic
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Identifiers
DOI
10.1038/SJ.CDD.4401456
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
PubMed ID
15243581
1 reference
stated in
Europe PubMed Central
PubMed ID
15243581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15243581%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
ResearchGate publication ID
8464840
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