(Q35847977)

English

Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells

scientific article published on 5 April 2005

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

indole-3-carbinol

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

Michael Andreeff

2

object named as

Michael Andreeff

1 reference

Europe PubMed Central

10 August 2017

PMC publication ID

author name string

Yasunari Takada

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Bharat B Aggarwal

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

0 references

publication date

5 April 2005

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

106

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

641-649

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1895177/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Nuclear factor-kappaB: a friend or a foe in cancer?

1 reference

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Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

1 reference

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Nuclear factor-kappaB: its role in health and disease

1 reference

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Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis

1 reference

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Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia

1 reference

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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

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Suppression of Inducible Nitric Oxide Production by Indole and Isothiocyanate Derivatives fromBrassicaPlants in Stimulated Macrophages

1 reference

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Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1

1 reference

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Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP.

1 reference

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Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Sensitizes Macrophages to Lipopolysaccharide-induced Nuclear Factor-κB, Mitogen-activated Protein Kinases, and Apoptosis

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Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

1 reference

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Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells

1 reference

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Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line.

1 reference

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Nuclear transcription factor-kappaB as a target for cancer drug development

1 reference

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Missing pieces in the NF-kappaB puzzle

1 reference

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11 July 2018

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines

1 reference

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11 July 2018

Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells

1 reference

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11 July 2018

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter

1 reference

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11 July 2018

Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells

1 reference

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A functional NF-kappaB binding site in the human papillomavirus type 16 long control region

1 reference

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11 July 2018

The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway

1 reference

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Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

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Mechanisms by which IkappaB proteins control NF-kappaB activity

1 reference

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Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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NF-kappaB activation: the I kappaB kinase revealed?

1 reference

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Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

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Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea

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Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation

1 reference

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Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol.

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Induction of estradiol metabolism by dietary indole-3-carbinol in humans

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Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice

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Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells

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Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas

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A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.

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Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis

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Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer

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Anti-metastatic activities of all-trans retinoic acid, indole-3-carbinol and (+)-catechin in Dunning rat invasive prostate adenocarcinoma cells

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Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells.

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Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats

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Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.

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Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol.

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Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice

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Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

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Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.

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Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol.

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Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants

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https://pubmed.ncbi.nlm.nih.gov/15811958

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Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection

1 reference

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Treatment of recurrent respiratory papillomatosis with indole-3-carbinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15811958

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Estrogen metabolism and laryngeal papillomatosis: a pilot study on dietary prevention

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Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1 reference

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Dietary indole-3-carbinol alters immune functions in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15811958

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Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15811958

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inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2004-12-4589

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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