(Q35876786)

English

The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1

scientific article published on 19 August 2011

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1 (English)

1 reference

Europe PubMed Central

10 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

7

object named as

Lei Liu

1 reference

Europe PubMed Central

10 August 2017

author name string

Zhu Yuan

1

1 reference

Europe PubMed Central

10 August 2017

Kang Cao

2

1 reference

Europe PubMed Central

10 August 2017

Chao Lin

3

1 reference

Europe PubMed Central

10 August 2017

Lei Li

4

1 reference

Europe PubMed Central

10 August 2017

Huan-yi Liu

5

1 reference

Europe PubMed Central

10 August 2017

Xin-yu Zhao

6

1 reference

Europe PubMed Central

10 August 2017

Hong-xin Deng

8

1 reference

Europe PubMed Central

10 August 2017

Jiong Li

9

1 reference

Europe PubMed Central

10 August 2017

Chun-lai Nie

10

1 reference

Europe PubMed Central

10 August 2017

Yu-quan Wei

11

1 reference

Europe PubMed Central

10 August 2017

language of work or name

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publication date

19 August 2011

1 reference

Europe PubMed Central

10 August 2017

Molecular Medicine

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Europe PubMed Central

10 August 2017

17

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Europe PubMed Central

10 August 2017

11-12

1 reference

Europe PubMed Central

10 August 2017

1262-1274

1 reference

Europe PubMed Central

10 August 2017

https://scigraph.springernature.com/pub.10.2119/molmed.2011.00176

0 references

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

PUMA, a potent killer with or without p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Tumor-specific adenovirus-mediated PUMA gene transfer using the survivin promoter enhances radiosensitivity of breast cancer cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Chemosensitization of head and neck cancer cells by PUMA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Absence of Bcl-xL down-regulation in response to cisplatin is associated with chemoresistance in ovarian carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Rapid turnover of mcl-1 couples translation to cell survival and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Efficient inhibition of intraperitoneal human ovarian cancer growth and prolonged survival by gene transfer of vesicular stomatitis virus matrix protein in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Novel therapeutic agents in ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Cancer statistics, 2006

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Bcl-X(L) is functionally non-equivalent for the regulation of growth and survival in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Proapoptotic BAX and BAK control multiple initiator caspases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Role of Bcl-xL in paracetamol-induced tubular epithelial cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Apoptosis in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Therapeutic exploitation of the p53 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

27 July 2018

Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Combination of MIG (CXCL9) chemokine gene therapy with low-dose cisplatin improves therapeutic efficacy against murine carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Cisplatin: from DNA damage to cancer chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Increased bcl-2 expression is associated with primary resistance to chemotherapy in human epithelial ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

p53 mutation is a common genetic event in ovarian carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321807

24 September 2018

The epidemiology of ovarian cancer

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00176

31 March 2020

Chemotherapy in the Management of Ovarian Carcinoma: A Review

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00176

31 March 2020

Nonparametric Estimation from Incomplete Observations

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00176

31 March 2020

Asymptotically Efficient Rank Invariant Test Procedures

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00176

31 March 2020

Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00176

31 March 2020

Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00176

31 March 2020

Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/21863213

12 December 2020

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inferred from PubMed ID database lookup

Induction of apoptosis by quercetin: involvement of heat shock protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21863213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21863213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21863213

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2119/MOLMED.2011.00176

1 reference

Europe PubMed Central

10 August 2017

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0 references

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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