(Q35894198)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

triple-negative breast cancer

26 January 2020

main subject

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

James W P Smyth

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

13

Laura J Esserman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

Ana Maria Gonzalez-Angulo

26 January 2020

6

object named as

Ana Maria Gonzalez-Angulo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

12

Gordon B Mills

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

author name string

Dai Horiuchi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Leonard Kusdra

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Noelle E Huskey

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Marc E Lenburg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Katelyn J Creasman

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Alexey V Bazarov

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Sarah E Davis

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Paul Yaswen

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Andrei Goga

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

language of work or name

English

0 references

publication date

19 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

26 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

page(s)

679-696

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

26 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3328367/fullTextXML

inferred from PubMed Central ID database lookup

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Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

27 July 2018

1 reference

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27 July 2018

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27 July 2018

1 reference

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Exploiting synthetic lethal interactions for targeted cancer therapy

27 July 2018

1 reference

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A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response

27 July 2018

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27 July 2018

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27 July 2018

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Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

27 July 2018

1 reference

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I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy

27 July 2018

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Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer

27 July 2018

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Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroup

27 July 2018

1 reference

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Triple-negative breast cancer: risk factors to potential targets

27 July 2018

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Reflecting on 25 years with MYC.

27 July 2018

1 reference

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What is triple-negative breast cancer?

27 July 2018

1 reference

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Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets

27 July 2018

1 reference

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

27 July 2018

1 reference

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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

27 July 2018

1 reference

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Multisite phosphorylation regulates Bim stability and apoptotic activity

27 July 2018

1 reference

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Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.

27 July 2018

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How basal are triple-negative breast cancers?

27 July 2018

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27 July 2018

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Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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27 July 2018

1 reference

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27 July 2018

1 reference

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27 July 2018

1 reference

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27 July 2018

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27 July 2018

1 reference

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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

27 July 2018

1 reference

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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27 July 2018

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Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer

27 July 2018

1 reference

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27 July 2018

1 reference

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Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma

27 July 2018

1 reference

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

27 July 2018

1 reference

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

27 July 2018

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

27 July 2018

1 reference

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Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.

27 July 2018

1 reference

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Intrinsic tumour suppression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Bim is a suppressor of Myc-induced mouse B cell leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

27 July 2018

1 reference

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

27 July 2018

1 reference

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Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival

27 July 2018

1 reference

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The Myc/Max/Mad network and the transcriptional control of cell behavior

27 July 2018

1 reference

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

27 July 2018

1 reference

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Molecular portraits of human breast tumours

27 July 2018

1 reference

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The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

c-Myc target genes involved in cell growth, apoptosis, and metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Bim: a novel member of the Bcl-2 family that promotes apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Oncogene protein co-expression. Value of Ha-ras, c-myc, c-fos, and p53 as prognostic discriminants for breast carcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Development of cell-cycle inhibitors for cancer therapy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Modelling Myc inhibition as a cancer therapy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Non-parametric quantification of protein lysate arrays

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Cyclin-dependent kinase pathways as targets for cancer treatment

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Gene expression profiling predicts clinical outcome of breast cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328367

Synergistic cooperation between c-Myc and Bcl-2 in lymph node progression of T1 human breast carcinomas

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20111512

Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22430491

12 December 2020

inferred from PubMed ID database lookup

Adaptive trials receive boost

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22430491

12 December 2020

inferred from PubMed ID database lookup

Altered subcellular localization of c-Myc protein identifies aggressive B-cell lymphomas harboring a c-MYC translocation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22430491

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1084/JEM.20111512

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PubMed publication ID

22430491

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22430491%20AND%20SRC:MED&resulttype=core&format=json