(Q35911142)

11 August 2017

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title

Pharmacogenetics of methotrexate (English)

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11 August 2017

Maja Krajinovic

1

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11 August 2017

Albert Moghrabi

series ordinal

2

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11 August 2017

publication date

1 October 2004

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11 August 2017

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11 August 2017

volume

5

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11 August 2017

issue

7

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11 August 2017

page(s)

819-834

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The genetic basis of variability in drug responses

11 August 2017

cites work

1 reference

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Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01.

21 January 2018

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The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX).

21 January 2018

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Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences

21 January 2018

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Molecular action of methotrexate in inflammatory diseases

21 January 2018

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Acute lymphoblastic leukemia in children

21 January 2018

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21 January 2018

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Pharmacogenetics and folate metabolism -- a promising direction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?

21 January 2018

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https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Intrinsic and acquired resistance to methotrexate in acute leukemia.

21 January 2018

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Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity

21 January 2018

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Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage

21 January 2018

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A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

21 January 2018

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A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity

21 January 2018

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A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

21 January 2018

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The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine

21 January 2018

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The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans

21 January 2018

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5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

21 January 2018

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Genotype and haplotype distributions of MTHFR677C>T and 1298A>C single nucleotide polymorphisms: a meta-analysis.

21 January 2018

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5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview

21 January 2018

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Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia

21 January 2018

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Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia

21 January 2018

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Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate

21 January 2018

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Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Methylenetetrahydrofolate reductase C677T polymorphism and toxicity in allogeneic hematopoietic cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

A Polymorphism, R653Q, in the Trifunctional Enzyme Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase/Formyltetrahydrofolate Synthetase Is a Maternal Genetic Risk Factor for Neural Tube Defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia

21 January 2018

1 reference

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Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Regulatory functions of 3'UTRs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Alternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Polymorphisms in genes involved in folate metabolism as risk factors for NTDs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

The pharmacology and clinical use of methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Identification of single nucleotide polymorphisms in the human γ-glutamyl hydrolase gene and characterization of promoter polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.5.7.819

21 January 2018

Identifiers

DOI

10.1517/14622416.5.7.819

1 reference

11 August 2017

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