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Small molecules reveal an alternative mechanism of Bax activation.
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Europe PubMed Central
PMC publication ID
4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
title
Small molecules reveal an alternative mechanism of Bax activation
(English)
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PMC publication ID
4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
author
David William Andrews
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5
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4847155
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9 March 2020
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Hetal Brahmbhatt
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1
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4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
David Uehling
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2
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4847155
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9 March 2020
Rima Al-Awar
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3
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4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
Brian Leber
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4
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4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
language of work or name
English
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publication date
25 February 2016
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4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
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Biochemical Journal
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4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
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9 March 2020
volume
473
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4847155
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9 March 2020
issue
8
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Europe PubMed Central
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4847155
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 March 2020
page(s)
1073-1083
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Europe PubMed Central
PMC publication ID
4847155
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 March 2020
copyright license
Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
start time
25 July 2019
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copyrighted
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ImageJ
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4847155/fullTextXML
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cites work
Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis
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PubMed Central
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Small-molecule Bax agonists for cancer therapy
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Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis
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BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response
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tBid undergoes multiple conformational changes at the membrane required for Bax activation
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Direct activation of full-length proapoptotic BAK
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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
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Bax dimerizes via a symmetric BH3:groove interface during apoptosis
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Prostaglandins antagonistically control Bax activation during apoptosis
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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
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Bcl-XL inhibits membrane permeabilization by competing with Bax.
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2 October 2017
Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis
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2 October 2017
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes
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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
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2 October 2017
JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
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2 October 2017
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
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2 October 2017
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat
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PubMed Central
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2 October 2017
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
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2 October 2017
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
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2 October 2017
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
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2 October 2017
Bax and Bak independently promote cytochrome C release from mitochondria
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2 October 2017
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
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2 October 2017
Structure of Bax: coregulation of dimer formation and intracellular localization
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PubMed Central
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2 October 2017
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
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PubMed Central
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2 October 2017
Cleavage of Bax enhances its cell death function
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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2 October 2017
Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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2 October 2017
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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2 October 2017
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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2 October 2017
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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2 October 2017
BID: a novel BH3 domain-only death agonist
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PubMed Central
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2 October 2017
Studies on the mechanism of membrane fusion: kinetics of calcium ion induced fusion of phosphatidylserine vesicles followed by a new assay for mixing of aqueous vesicle contents
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PubMed Central
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2 October 2017
Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid
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PubMed Central
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11 July 2018
S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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24 September 2018
Expression, purification and use of recombinant annexin V for the detection of apoptotic cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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24 September 2018
Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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24 September 2018
Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4847155
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24 September 2018
Nonionic detergents induce dimerization among members of the Bcl-2 family
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26916338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impact of pH on Bax alpha conformation, oligomerisation and mitochondrial integration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26916338
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1042/BCJ20160118
1 reference
stated in
Europe PubMed Central
PMC publication ID
4847155
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 March 2020
PMC publication ID
4847155
1 reference
stated in
Europe PubMed Central
PMC publication ID
4847155
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 March 2020
PubMed publication ID
26916338
1 reference
stated in
Europe PubMed Central
PMC publication ID
4847155
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26916338%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 March 2020
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