(Q36028231)

11 August 2017

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title

Genetic aspects of immune-mediated adverse drug effects (English)

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11 August 2017

Peter J Bugelski

1

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11 August 2017

1 January 2005

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Nature Reviews Drug Discovery

11 August 2017

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11 August 2017

4

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11 August 2017

59-69

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11 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrd1605

11 August 2017

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Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine

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Cephalosporin allergy

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Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

21 January 2018

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Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

21 January 2018

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Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

21 January 2018

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31 March 2020

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A review of the common properties of drugs with idiosyncratic hepatotoxicity and the "multiple determinant hypothesis" for the manifestation of idiosyncratic drug toxicity.

31 March 2020

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Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions

31 March 2020

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Immunoregulation of hapten and drug induced immune reactions

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The danger hypothesis--potential role in idiosyncratic drug reactions

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Drug-induced autoimmunity

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31 March 2020

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Functional consequences of polymorphism of xenobiotic metabolising enzymes

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31 March 2020

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Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity

31 March 2020

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Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

31 March 2020

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Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation

31 March 2020

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UDP-Glucuronosyltransferases

31 March 2020

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31 March 2020

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31 March 2020

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Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (Lmp-2).

31 March 2020

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Gene polymorphisms within the immune system that may underlie drug allergy

31 March 2020

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31 March 2020

1 reference

HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis

31 March 2020

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Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma☆

31 March 2020

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Association of pyrazolone drug hypersensitivity with HLA-DQ and DR antigens

31 March 2020

1 reference

Association of HLA-DR11 with the anaphylactoid reaction caused by nonsteroidal anti-inflammatory drugs

31 March 2020

1 reference

Delayed hypersensitivity to aminopenicillins is related to major histocompatibility complex genes

31 March 2020

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Evaluation of liver function in type 2 diabetic patients during clinical trials: evidence that rosiglitazone does not cause hepatic dysfunction

31 March 2020

1 reference

Quantitation of cytokine mRNA expression as an endpoint for prediction and diagnosis of xenobiotic-induced hypersensitivity reactions

31 March 2020

1 reference

Polymorphism of phase II enzymes: identification of new enzymes and polymorphic variants by database analysis

31 March 2020

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Pharmacogenetic and pharmacogenomic studies. Impact on drug discovery and drug development

31 March 2020

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Value of animal models for predicting hypersensitivity reactions to medicinal products

31 March 2020

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HLA transgenic mice as humanized mouse models of disease and immunity.

31 March 2020

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HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis

31 March 2020

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Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

31 March 2020

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Enhanced contact hypersensitivity in human monocyte chemoattractant protein-1 transgenic mouse

31 March 2020

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Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

31 March 2020

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Tolerance, danger, and the extended family

31 March 2020

1 reference

Drug-induced allergic hepatitis

31 March 2020

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Type III and type IV hypersensitivity reactions due to mitomycin C

31 March 2020

1 reference

T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction

31 March 2020

1 reference

Sulfonamide-reactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions

31 March 2020

1 reference

Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management

31 March 2020

1 reference

Immunochemical Mechanisms of Penicillin Induced Coombs Positivity and Hemolytic Anemia in Man

31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1605

1 reference

11 August 2017

1 reference

PubMed ID

15688073