(Q36045121)

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Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22543039%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22543039%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

subtilisin-like protease 1

1 reference

10 September 2018

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Catherine Suarez

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22543039%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Jean-Paul Ebejer

6

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30 January 2020

Konstantinos Koussis

7

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30 January 2020

Michael J Blackman

11

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Michael J Blackman

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30 January 2020

8

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Fiona Hackett

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30 January 2020

Chrislaine Withers-Martinez

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Chrislaine Withers-Martinez

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30 January 2020

author name string

Simone Fulle

3

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30 January 2020

Samir Kher

4

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30 January 2020

Maria Penzo

5

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30 January 2020

Aigars Jirgensons

9

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30 January 2020

Paul Finn

10

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30 January 2020

publication date

27 April 2012

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30 January 2020

International Journal for Parasitology

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30 January 2020

42

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30 January 2020

6

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30 January 2020

597-612

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30 January 2020

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

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2 October 2017

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

1 reference

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2 October 2017

1 reference

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Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

1 reference

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2 October 2017

Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin

1 reference

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2 October 2017

The proprotein convertases, 20 years later

1 reference

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2 October 2017

Structure and function of tripeptidyl peptidase II, a giant cytosolic protease

1 reference

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2 October 2017

Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia

1 reference

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2 October 2017

Clues to evolution of the SERA multigene family in 18 Plasmodium species

1 reference

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2 October 2017

Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease

1 reference

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2 October 2017

The Journey to the Discovery of Boceprevir: An NS3–NS4 HCV Protease Inhibitor for the Treatment of Chronic Hepatitis C

1 reference

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2 October 2017

Regulated maturation of malaria merozoite surface protein‐1 is essential for parasite growth

1 reference

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2 October 2017

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

1 reference

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2 October 2017

Features and development of Coot

1 reference

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2 October 2017

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite

1 reference

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2 October 2017

New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance

1 reference

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2 October 2017

A multifunctional serine protease primes the malaria parasite for red blood cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Protein structure modeling with MODELLER

1 reference

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2 October 2017

Malarial proteases and host cell egress: an 'emerging' cascade

1 reference

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2 October 2017

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

1 reference

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2 October 2017

Vivax malaria: neglected and not benign

1 reference

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2 October 2017

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Molecular identification of a malaria merozoite surface sheddase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

The Amber biomolecular simulation programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Characterization of events preceding the release of malaria parasite from the host red blood cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

All-Atom Structure Prediction and Folding Simulations of a Stable Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

A clogged gutter mechanism for protease inhibitors

1 reference

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2 October 2017

Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378952

2 October 2017

Malaria parasite exit from the host erythrocyte: a two-step process requiring extraerythrocytic proteolysis

1 reference

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2 October 2017

Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

1 reference

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2 October 2017

The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution

1 reference

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2 October 2017

A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites

1 reference

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2 October 2017

The complete sequence of Plasmodium berghei merozoite surface protein-1 and its inter- and intra-species variability

1 reference

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2 October 2017

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

1 reference

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2 October 2017

Subtilases: the superfamily of subtilisin-like serine proteases

1 reference

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2 October 2017

The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'

1 reference

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2 October 2017

On the size of the active site in proteases. I. Papain

1 reference

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2 October 2017

Designing substrate specificity by protein engineering of electrostatic interactions

1 reference

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2 October 2017

The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry

1 reference

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2 October 2017

Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering

1 reference

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2 October 2017

Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo

1 reference

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2 October 2017

Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes

1 reference

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2 October 2017

Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 A resolution

1 reference

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2 October 2017

Complex between the subtilisin from a mesophilic bacterium and the Leech inhibitor eglin-C

1 reference

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2 October 2017

Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate

1 reference

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Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin

1 reference

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Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

1 reference

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23 September 2018

Clonal conditional mutagenesis in malaria parasites

1 reference

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23 September 2018

Characterization of bacterial proteases with a panel of fluorescent peptide substrates

1 reference

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23 September 2018

Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity

1 reference

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23 September 2018

Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte

1 reference

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23 September 2018

A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage

1 reference

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23 September 2018

Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease

1 reference

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23 September 2018

Validation of protein models derived from experiment

1 reference

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23 September 2018

Plasmodium knowlesi: studies on invasion of rhesus erythrocytes by merozoites in the presence of protease inhibitors

1 reference

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23 September 2018

A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum

1 reference

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23 September 2018

Identifiers

10.1016/J.IJPARA.2012.04.005

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22543039%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22543039%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22543039%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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