(Q36046503)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor kinase 2 Dmel_CG17998

13 March 2020

main subject

1 reference

GOA release 2020-03-11

author

Yuhong Han

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

author name string

Shuangxi Li

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Shuang Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Chao Tong

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Bing Wang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Yongbin Chen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Jin Jiang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

language of work or name

English

0 references

publication date

9 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

page(s)

e1002481

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 March 2020

copyright license

start time

9 June 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

1 reference

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Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila

2 October 2017

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Roles for Hedgehog signaling in adult organ homeostasis and repair

2 October 2017

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A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity

2 October 2017

1 reference

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Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation

2 October 2017

1 reference

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The mechanisms of Hedgehog signalling and its roles in development and disease

2 October 2017

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Decoding the phosphorylation code in Hedgehog signal transduction

2 October 2017

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The Hedgehog signal transduction network

2 October 2017

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Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

2 October 2017

1 reference

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Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.

2 October 2017

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Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

2 October 2017

1 reference

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USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization

2 October 2017

1 reference

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The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

2 October 2017

1 reference

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Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

2 October 2017

1 reference

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Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila

2 October 2017

1 reference

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Mechanism and evolution of cytosolic Hedgehog signal transduction

2 October 2017

1 reference

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Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

2 October 2017

1 reference

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The structure and function of G-protein-coupled receptors

2 October 2017

1 reference

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Hedgehog signaling in development and cancer.

2 October 2017

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Hedgehog regulates smoothened activity by inducing a conformational switch

2 October 2017

1 reference

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Patched1 regulates hedgehog signaling at the primary cilium

2 October 2017

1 reference

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

2 October 2017

1 reference

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Vertebrate Smoothened functions at the primary cilium

2 October 2017

1 reference

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The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

2 October 2017

1 reference

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Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

2 October 2017

1 reference

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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

2 October 2017

1 reference

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Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

2 October 2017

1 reference

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Hedgehog signalling in cancer formation and maintenance

2 October 2017

1 reference

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Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

2 October 2017

1 reference

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Hedgehog signaling in animal development: paradigms and principles

2 October 2017

1 reference

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The Hedgehog and Wnt signalling pathways in cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development

2 October 2017

1 reference

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Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Dual roles for patched in sequestering and transducing Hedgehog

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Protein kinase A and hedgehog signaling in Drosophila limb development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Minutes: Mutants of Drosophila autonomously affecting cell division rate

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Regulation of wingless signaling by the CKI family in Drosophila limb development.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Casein kinase I transduces Wnt signals

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900676

10.1371/JOURNAL.PBIO.1002481

23 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27280464%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

27280464

1 reference