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Mechanism and evolution of cytosolic Hedgehog signal transduction
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scholarly article
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stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
review article
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stated in
Europe PubMed Central
title
Mechanism and evolution of cytosolic Hedgehog signal transduction
(English)
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stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
author name string
Christopher W Wilson
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
Pao-Tien Chuang
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
language of work or name
English
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publication date
1 July 2010
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stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
number of pages
16
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inferred from page(s)
published in
Development
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stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
volume
137
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stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
page(s)
2079-2094
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
issue
13
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
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The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
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Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
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A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
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Beta-arrestin-mediated localization of smoothened to the primary cilium
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Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
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Hedgehog regulates smoothened activity by inducing a conformational switch
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5 July 2018
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.
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5 July 2018
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
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5 July 2018
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
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5 July 2018
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation
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5 July 2018
Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.
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5 July 2018
Functional dissection of Rab GTPases involved in primary cilium formation
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5 July 2018
Patched1 regulates hedgehog signaling at the primary cilium
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5 July 2018
Cilia and developmental signaling
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5 July 2018
The graded response to Sonic Hedgehog depends on cilia architecture
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5 July 2018
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.
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5 July 2018
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
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5 July 2018
A conserved mechanism of Hedgehog gradient formation by lipid modifications
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5 July 2018
Keeping transcriptional activators under control
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5 July 2018
Mediator modulates Gli3-dependent Sonic hedgehog signaling
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5 July 2018
The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
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5 July 2018
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
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5 July 2018
Activation of heterotrimeric G proteins by Smoothened
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5 July 2018
The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling
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PubMed Central
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5 July 2018
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.
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5 July 2018
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
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5 July 2018
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
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PubMed Central
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5 July 2018
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
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PubMed Central
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5 July 2018
Cholesterol modification restricts the spread of Shh gradient in the limb bud.
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5 July 2018
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
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5 July 2018
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
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5 July 2018
Dual degradation signals control Gli protein stability and tumor formation
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5 July 2018
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
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5 July 2018
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
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5 July 2018
Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins
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5 July 2018
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
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5 July 2018
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Vertebrate Smoothened functions at the primary cilium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Analysis of the kinesin superfamily: insights into structure and function
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Cilia and Hedgehog responsiveness in the mouse
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Lipoprotein particles are required for Hedgehog and Wingless signalling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Transduction of receptor signals by beta-arrestins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Communicating with Hedgehogs
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Characterization of KIF7 gene in silico.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
KIF27 is one of orthologs for Drosophila Costal-2.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
The Hedgehog response network: sensors, switches, and routers
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Hedgehog signalling in the mouse requires intraflagellar transport proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
How the ubiquitin-proteasome system controls transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
The evolution of signalling pathways in animal development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Developmental roles and clinical significance of hedgehog signaling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Similarities between the Hedgehog and Wnt signaling pathways
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Intraflagellar transport
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Patched acts catalytically to suppress the activity of Smoothened
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Sonic hedgehog induces the segregation of patched and smoothened in endosomes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Gli1 can rescue the in vivo function of Gli2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
A freely diffusible form of Sonic hedgehog mediates long-range signalling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
An absolute requirement for Cubitus interruptus in Hedgehog signaling.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Gli regulation by the opposing activities of fused and suppressor of fused
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Identification of a palmitic acid-modified form of human Sonic hedgehog
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Altered neural cell fates and medulloblastoma in mouse patched mutants
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Biochemical evidence that patched is the Hedgehog receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
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5 July 2018
Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Cholesterol modification of hedgehog signaling proteins in animal development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Sertoli cell signaling by Desert hedgehog regulates the male germline
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Autoproteolysis in hedgehog protein biogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Proteolytic processing yields two secreted forms of sonic hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Mutations affecting segment number and polarity in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
5 July 2018
Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Patching the gaps in Hedgehog signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Genetic dissection of the Drosophila Cubitus interruptus signaling complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Identification of a tetrameric hedgehog signaling complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2882129
retrieved
29 October 2018
Smoothened activates Galphai-mediated signaling in frog melanophores
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20530542
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1242/DEV.045021
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
PMCID
2882129
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
PubMed ID
20530542
1 reference
stated in
Europe PubMed Central
PubMed ID
20530542
retrieved
29 July 2017
ResearchGate publication ID
44656274
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