(Q40285122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

main subject

protein ubiquitination

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author name string

Neehar Bhatia

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Saravanan Thiyagarajan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Irina Elcheva

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Andrzej Dlugosz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Hasan Mukhtar

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Vladimir S Spiegelman

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

language of work or name

English

0 references

publication date

1 May 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

20 January 2020

number of pages

7

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

page(s)

19320-19326

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16651270%20AND%20SRC:MED&resulttype=core&format=json

Pathways and consequences: Hedgehog signaling in human disease.

20 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Gli and hedgehog in cancer: tumours, embryos and stem cells.

21 January 2018

1 reference

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Gli genes in development and cancer

21 January 2018

1 reference

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Hedgehog signalling in cancer formation and maintenance

21 January 2018

1 reference

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The Hedgehog response network: sensors, switches, and routers

21 January 2018

1 reference

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Hedgehog: an unusual signal transducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

The Gli2 transcription factor is required for normal mouse mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

21 January 2018

1 reference

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Hedgehog signaling promotes prostate xenograft tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Activation of the hedgehog pathway in advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Regulation of the cell cycle by SCF-type ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Inhibition of HOS expression and activities by Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Basal cell carcinomas in mice overexpressing Gli2 in skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200

Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513203200