(Q36049945)

11 August 2017

Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. (English)

1 reference

11 August 2017

Lauren S Vaughn

1

1 reference

11 August 2017

D Cristopher Bragg

2

1 reference

11 August 2017

Nutan Sharma

3

1 reference

11 August 2017

Sarah Camargos

4

1 reference

11 August 2017

Francisco Cardoso

5

1 reference

11 August 2017

Rekha C Patel

6

1 reference

11 August 2017

language of work or name

English

0 references

publication date

31 July 2015

1 reference

Journal of Biological Chemistry

11 August 2017

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11 August 2017

290

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11 August 2017

37

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11 August 2017

22543-22557

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describes a project that uses

11 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4566229/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs

1 reference

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dsRNA binding protein PACT/RAX in gene silencing, development and diseases

2 October 2017

1 reference

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Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

2 October 2017

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Recent advances in the genetics of dystonia

2 October 2017

1 reference

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The impact of PKR activation: from neurodegeneration to cancer.

2 October 2017

1 reference

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TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.

2 October 2017

1 reference

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Endoplasmic reticulum stress: its role in disease and novel prospects for therapy

2 October 2017

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The eIF2α kinases: their structures and functions

2 October 2017

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

2 October 2017

1 reference

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The PKR activator PACT is induced by Aβ: involvement in Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Exploring the influence of torsinA expression on protein quality control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Molecular pathways in dystonia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Mutations in the THAP1 gene are responsible for DYT6 primary torsion dystonia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Genetics of dystonia: an overview

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Activation of PKR: an open and shut case?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

The diagnosis of dystonia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

The double-stranded RNA-binding motif, a versatile macromolecular docking platform

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Modular structure of PACT: distinct domains for binding and activating PKR

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

PACT, a protein activator of the interferon-induced protein kinase, PKR.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Mapping of interacting domains between the nucleocapsid protein and the phosphoprotein of vesicular stomatitis virus by using a two-hybrid system

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Novel compound heterozygous mutations in PRKRA cause pure dystonia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

A novel presentation of DYT 16: acute onset in infancy and association with MRI abnormalities.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Increased interaction between PACT molecules in response to stress signals is required for PKR activation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

Use of cyclosporin A in establishing Epstein-Barr virus-transformed human lymphoblastoid cell lines

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566229

DYT16: a new twist to familial dystonia

23 September 2018

1 reference

12 December 2020

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI

1 reference

12 December 2020

1 reference

12 December 2020

A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient

1 reference

12 December 2020

DYT16: the original cases

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M115.669408

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

26231208

1 reference