(Q36067060)

12 August 2017

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title

Therapeutic gene silencing in neurological disorders, using interfering RNA. (English)

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12 August 2017

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3

Mimoun Azzouz

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12 August 2017

G Scott Ralph

1

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12 August 2017

Nicholas D Mazarakis

series ordinal

2

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12 August 2017

publication date

10 March 2005

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Journal of Molecular Medicine

12 August 2017

published in

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12 August 2017

volume

83

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12 August 2017

issue

6

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12 August 2017

page(s)

413-419

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Receptor-targeted gene delivery using multivalent phagemid particles

12 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS00109-005-0649-1

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

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VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

21 January 2018

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Local gene knockdown in the brain using viral-mediated RNA interference.

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12 December 2020

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

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Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target

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Activation of the interferon system by short-interfering RNAs

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12 December 2020

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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Retroviral delivery of small interfering RNA into primary cells

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Picking a winner: new mechanistic insights into the design of effective siRNAs

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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

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Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

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Adenovirus vector-mediated doxycycline-inducible RNA interference

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Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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Lentiviral vectors for the treatment of neurodegenerative diseases.

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

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A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

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Lentiviral vectors for treating and modeling human CNS disorders

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U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

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Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression

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12 December 2020

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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Rational siRNA design for RNA interference

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Small interfering RNA and gene silencing in transgenic mice and rats

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

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Pathogenesis of polyglutamine disorders: aggregation revisited

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Genetic clues to the pathogenesis of Parkinson's disease

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

Germline transmission of RNAi in mice

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12 December 2020

Plasticity and the spread of Alzheimer's disease-like changes

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12 December 2020

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

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12 December 2020

Invasive drug delivery.

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12 December 2020

Allele-specific silencing of dominant disease genes

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12 December 2020

Specific gene inhibition by adenovirus-mediated expression of small interfering RNA

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12 December 2020

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

Effective expression of small interfering RNA in human cells

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12 December 2020

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12 December 2020

Expression profiling reveals off-target gene regulation by RNAi

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Superoxide dismutase 1 knock-down induces senescence in human fibroblasts

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12 December 2020

RNAi functions in cultured mammalian neurons

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12 December 2020

How cells respond to interferons

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12 December 2020

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

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12 December 2020

dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference

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12 December 2020

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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12 December 2020

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

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12 December 2020

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

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12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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12 December 2020

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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12 December 2020

Huntingtin in health and disease

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12 December 2020

Role for a bidentate ribonuclease in the initiation step of RNA interference

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12 December 2020

siRNAs can function as miRNAs

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12 December 2020

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

1 reference

12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

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12 December 2020

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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12 December 2020

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

1 reference

12 December 2020

10.1007/S00109-005-0649-1

Identifiers

DOI

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12 August 2017

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