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Modelling oncogenic Ras/Raf signalling in the mouse.
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scholarly article
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Q5412157
PMCID
3389704
retrieved
12 August 2017
review article
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Q5412157
title
Modelling oncogenic Ras/Raf signalling in the mouse.
(English)
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Q5412157
PMCID
3389704
retrieved
12 August 2017
author
David Tuveson
series ordinal
2
object named as
David A Tuveson
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Q5412157
PMCID
3389704
retrieved
12 August 2017
author name string
Florian A Karreth
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1
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Q5412157
PMCID
3389704
retrieved
12 August 2017
publication date
7 February 2009
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Q5412157
PMCID
3389704
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12 August 2017
published in
Current Opinion in Genetics & Development
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Q5412157
PMCID
3389704
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12 August 2017
volume
19
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Q5412157
PMCID
3389704
retrieved
12 August 2017
page(s)
4-11
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Q5412157
PMCID
3389704
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12 August 2017
issue
1
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Q5412157
PMCID
3389704
retrieved
12 August 2017
cites work
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Constitutive activation of Raf-1 induces glioma formation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Sprouty proteins, masterminds of receptor tyrosine kinase signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Maximizing mouse cancer models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Hyperactive Ras in developmental disorders and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Neurofibromatosis type 1 - a model for nervous system tumour formation?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Identification of bronchioalveolar stem cells in normal lung and lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Raf proteins and cancer: B-Raf is identified as a mutational target
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Targeting RAS signalling pathways in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
High frequency of BRAF mutations in nevi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Genetic and epigenetic alterations in colon cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Mutations of the BRAF gene in human cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
ras oncogenes in human cancer: a review
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
2 October 2017
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
11 July 2018
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
1 reference
stated in
PubMed Central
reference URL
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retrieved
11 July 2018
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1 reference
stated in
PubMed Central
reference URL
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retrieved
11 July 2018
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.
1 reference
stated in
PubMed Central
reference URL
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retrieved
23 September 2018
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1 reference
stated in
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reference URL
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retrieved
23 September 2018
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1 reference
stated in
PubMed Central
reference URL
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retrieved
23 September 2018
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
23 September 2018
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
23 September 2018
The discovery of receptor tyrosine kinases: targets for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
23 September 2018
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389704
retrieved
23 September 2018
Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BRAF and RAS mutations in human lung cancer and melanoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The differential effects of mutant p53 alleles on advanced murine lung cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19201597
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.GDE.2008.12.006
1 reference
stated in
Q5412157
PMCID
3389704
retrieved
12 August 2017
Fatcat ID
release_xenomsv4abctbdyhnbl4jle7tu
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Fatcat
reference URL
https://api.fatcat.wiki/v0/release/xenomsv4abctbdyhnbl4jle7tu
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24 November 2022
based on heuristic
mapped directly with Wikidata item
PMCID
3389704
1 reference
stated in
Q5412157
PMCID
3389704
retrieved
12 August 2017
PubMed ID
19201597
1 reference
stated in
Q5412157
PMCID
3389704
retrieved
12 August 2017
ResearchGate publication ID
23989042
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