(Q36131601)

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Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

small cell carcinoma

1 reference

based on heuristic

inferred from title

prostate cancer

1 reference

based on heuristic

inferred from title

Kunal C Kadakia

object named as

Kunal C Kadakia

1

0 references

Daniel H Hovelson

object named as

Daniel H Hovelson

6

0 references

Kathleen A. Cooney

object named as

Kathleen A Cooney

8

0 references

Scott A. Tomlins

2

object named as

Scott A Tomlins

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

author name string

Saagar K Sanghvi

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Andi K Cani

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Kei Omata

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Chia-Jen Liu

7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

publication date

6 October 2015

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Journal of Hematology & Oncology

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

109

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Spatial genomic heterogeneity within localized, multifocal prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Frequency of TERT Promoter Mutations in Prostate Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Distinct genetic alterations in small cell carcinoma from different anatomic sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors

1 reference

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2 October 2017

Targeted therapies for small cell lung cancer: Where do we stand?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Integrative molecular profiling of routine clinical prostate cancer specimens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Targeting neuroendocrine prostate cancer: molecular and clinical perspectives

1 reference

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2 October 2017

Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma

1 reference

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2 October 2017

Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data

1 reference

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2 October 2017

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

1 reference

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2 October 2017

Strategies for modern biomarker and drug development in oncology

1 reference

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2 October 2017

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

High frequency of TERT promoter mutation in small cell carcinoma of bladder, but not in small cell carcinoma of other origins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Small-cell lung cancers in patients who never smoked cigarettes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

The many faces of neuroendocrine differentiation in prostate cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Epithelial plasticity: a common theme in embryonic and cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

"N of 1" case reports in the era of whole-genome sequencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Cross modulation between the androgen receptor axis and protocadherin-PC in mediating neuroendocrine transdifferentiation and therapeutic resistance of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Targeting p53 by small molecules in hematological malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Midkine is associated with neuroendocrine differentiation in castration-resistant prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Genome sequencing identifies a basis for everolimus sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Survival of patients with small cell carcinoma of the prostate during 1973-2003: a population-based study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signatures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Small-cell neuroendocrine carcinoma as a variant form of prostate cancer recurrence: a case report and short literature review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 October 2017

Tumor evolution and progression in multifocal and paired non-invasive/invasive urothelial carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 July 2018

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 July 2018

Tracking the clonal origin of lethal prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 July 2018

ERG gene rearrangements are common in prostatic small cell carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 July 2018

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

2 July 2018

Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

23 September 2018

Exceptional responders: in search of the science behind the miracle cancer cures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596504

23 September 2018

Androgen-Independent Prostate Cancer Is a Heterogeneous Group of Diseases

1 reference

https://api.crossref.org/works/10.1186%2FS13045-015-0204-7

21 January 2018

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26444865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression of prostate cancer to neuroendocrine cell tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26444865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17

1 reference

https://pubmed.ncbi.nlm.nih.gov/26444865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S13045-015-0204-7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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