(Q36143261)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

0 references

2

1 reference

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22 February 2020

author name string

Paritha I Arumugam

1

1 reference

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22 February 2020

Shiva Kumar Shanmukhappa

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Brett P Monia

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Anastacia Loberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Maureen A Shaw

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Tilat Rizvi

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Janaka Wansapura

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Jay L Degen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Punam Malik

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

language of work or name

English

0 references

publication date

18 August 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

1844-1855

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

Factor XI antisense oligonucleotide for prevention of venous thrombosis

22 February 2020

cites work

1 reference

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Antisense oligonucleotide therapies: the promise and the challenges from a toxicologic pathologist's perspective

2 October 2017

1 reference

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Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype

2 October 2017

1 reference

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Thrombin drives tumorigenesis in colitis-associated colon cancer

2 October 2017

1 reference

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Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

2 October 2017

1 reference

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Extracellular hemin crisis triggers acute chest syndrome in sickle mice

2 October 2017

1 reference

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Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

2 October 2017

1 reference

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Association of coagulation activation with clinical complications in sickle cell disease

2 October 2017

1 reference

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Protease-activated receptor 2 signaling in inflammation

2 October 2017

1 reference

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Sickle cell nephropathy - a practical approach

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Plasma annexin A5 and microparticle phosphatidylserine levels are elevated in sickle cell disease and increase further during painful crisis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Sickle cell disease and stroke

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Coagulation and anticoagulation in pulmonary arterial hypertension

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Critical roles for thrombin in acute and chronic inflammation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Morphological and functional platelet abnormalities in Berkeley sickle cell mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Hypercoagulability in sickle cell disease: new approaches to an old problem

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Leukocyte adhesion and thrombosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Protease-activated receptors: contribution to physiology and disease

2 October 2017

1 reference

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Antisense oligonucleotide-based therapeutics for cancer

2 October 2017

1 reference

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Hemostatic alterations in sickle cell disease: relationships to disease pathophysiology

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment

2 October 2017

1 reference

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Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

The hypercoagulable state in thalassemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Thrombin signalling and protease-activated receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Management of sickle cell disease.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Tissue factor expression by endothelial cells in sickle cell anemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Airway hyperreactivity in children with sickle cell disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Transgenic and gene knock-out mouse models of sickle cell anemia and the thalassemias.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

First report of reversal of organ dysfunction in sickle cell anemia by the use of hydroxyurea: splenic regeneration.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Preliminary trial of minidose heparin prophylaxis for painful sickle cell crises.

2 October 2017

1 reference

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Hypercoagulability and thrombotic complications in hemolytic anemias.

2 October 2017

1 reference

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Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Prothrombotic changes in children with sickle cell disease: relationships to cerebrovascular disease and transfusion.

2 July 2018

1 reference

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Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease.

2 July 2018

1 reference

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Hemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

A hemodynamic study of pulmonary hypertension in sickle cell disease.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Airway hyperreactivity detected by methacholine challenge in children with sickle cell disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Rescue of prothrombin-deficiency by transgene expression in mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Folate status assessment and folic acid supplements in sickle cell disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Pathogenesis and treatment of sickle cell disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Mortality in sickle cell disease. Life expectancy and risk factors for early death.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Therapeutic effect of aspirin in sickle cell anaemia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600020

Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease

23 September 2018

1 reference

12 December 2020

Long-term anti-coagulation in sickle-cell disease. A clinical study

1 reference

12 December 2020

Endothelial function in patients with sickle cell anemia during and after sickle cell crises

1 reference

12 December 2020

Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation

1 reference

12 December 2020

Glomerular involvement in adults with sickle cell hemoglobinopathies: Prevalence and clinical correlates of progressive renal failure

1 reference

12 December 2020

Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial

1 reference

12 December 2020

No association of the hypercoagulable state with sickle cell disease related pulmonary hypertension

1 reference

12 December 2020

Hypoxia induces different genes in the lungs of rats compared with mice

1 reference

12 December 2020

A comparison of conservative and aggressive transfusion regimens in the perioperative management of sickle cell disease. The Preoperative Transfusion in Sickle Cell Disease Study Group

1 reference

12 December 2020

Low-intensity oral anticoagulation in sickle-cell disease reverses the prethrombotic state: promises for treatment?

1 reference

12 December 2020

Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion

1 reference

12 December 2020

Thrombogenesis in sickle cell disease

1 reference

12 December 2020

Asthma and acute chest in sickle-cell disease

1 reference

12 December 2020

Occlusion of Large Cerebral Vessels in Sickle-Cell Anemia

1 reference

12 December 2020

Aspirin-dipyridamole prophylaxis of sickle cell disease pain crises

1 reference

12 December 2020

Trial of low doses of aspirin as prophylaxis in sickle cell disease

1 reference

12 December 2020

Treatment of sickle cell diseases with aspirin

1 reference

12 December 2020

Clinical and biological double-blind-study of ticlopidine in preventive treatment of sickle-cell disease crises

1 reference

12 December 2020

A double-blind trial of ticlopidine in sickle cell disease

1 reference

12 December 2020

Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst

1 reference

12 December 2020

Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometric measurement and clinical associations

1 reference

12 December 2020

Sickle cell disease and the kidney

1 reference

12 December 2020

Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease

1 reference

12 December 2020

Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation

1 reference

12 December 2020

Sickle red blood cells stimulate endothelial cell production of eicosanoids and diacylglycerol

1 reference

12 December 2020

10.1182/BLOOD-2015-01-625707

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26286849%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference