(Q36174012)

12 August 2017

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title

Ageing and metabolism: drug discovery opportunities (English)

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12 August 2017

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Rory Curtis

1

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PubMed ID

15976816

12 August 2017

Bard J Geesaman

series ordinal

2

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PubMed ID

15976816

12 August 2017

Peter S DiStefano

series ordinal

3

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12 August 2017

1 July 2005

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Nature Reviews Drug Discovery

12 August 2017

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12 August 2017

4

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12 August 2017

7

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12 August 2017

569-580

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https://scigraph.springernature.com/pub.10.1038/nrd1777

12 August 2017

0 references

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

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Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Molecular chaperones in the cytosol: from nascent chain to folded protein

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Heat-shock proteins as regulators of apoptosis

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

21 January 2018

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The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

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A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast

21 January 2018

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The AMP-activated protein kinase pathway--new players upstream and downstream.

21 January 2018

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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

21 January 2018

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

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Insulin and longevity: antidiabetic biguanides as geroprotectors

21 January 2018

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Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins

21 January 2018

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C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue

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Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.

21 January 2018

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Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

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Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

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Long-lived Drosophila with overexpressed dFOXO in adult fat body

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Adipose tissue as an endocrine organ

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Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression

21 January 2018

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Long-term complications of diabetes mellitus

21 January 2018

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Evolution, stress, and longevity

21 January 2018

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Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

21 January 2018

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Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

21 January 2018

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

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Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome

21 January 2018

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

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Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

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Characterization of the insulin resistance of aging

21 January 2018

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Contribution of visceral fat mass to the insulin resistance of aging.

21 January 2018

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21 January 2018

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Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

21 January 2018

1 reference

Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study

21 January 2018

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Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

21 January 2018

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Insulin resistance as a predictor of age-related diseases

21 January 2018

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21 January 2018

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Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women

21 January 2018

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Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery

21 January 2018

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21 January 2018

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21 January 2018

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Sustained weight loss in obese subjects has benefits that are independent of attained weight

21 January 2018

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21 January 2018

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Is There a Role for ??-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?

21 January 2018

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Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial

21 January 2018

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Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

21 January 2018

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Orlistat, a new lipase inhibitor for the management of obesity

21 January 2018

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Efficacy and safety of sibutramine in obese white and African American patients with hypertension: a 1-year, double-blind, placebo-controlled, multicenter trial

21 January 2018

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Obesity wars: molecular progress confronts an expanding epidemic

21 January 2018

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High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

21 January 2018

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Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist

21 January 2018

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Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

21 January 2018

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Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease

21 January 2018

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

21 January 2018

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Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

21 January 2018

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Inflammatory mediators in the elderly

21 January 2018

1 reference

Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study

21 January 2018

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C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

21 January 2018

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Atherosclerosis. the road ahead

21 January 2018

1 reference

Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study.

21 January 2018

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

21 January 2018

1 reference

Anti-TNF-alpha therapies: the next generation

21 January 2018

1 reference

Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis

21 January 2018

1 reference

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise

21 January 2018

1 reference

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

21 January 2018

1 reference

Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

21 January 2018

1 reference

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

21 January 2018

1 reference

5' adenosine monophosphate-activated protein kinase, metabolism and exercise

21 January 2018

1 reference

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

21 January 2018

1 reference

Metformin: new understandings, new uses

21 January 2018

1 reference

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

The TOR pathway: a target for cancer therapy

21 January 2018

1 reference

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 January 2018

1 reference

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

21 January 2018

1 reference

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

21 January 2018

1 reference

Evolutionary medicine: from dwarf model systems to healthy centenarians?

21 January 2018

1 reference

Can Growth Hormone (GH) Accelerate Aging? Evidence from GH-Transgenic Mice

21 January 2018

1 reference

Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?

21 January 2018

1 reference

Comparing adiposity profiles in three mouse models with altered GH signaling

21 January 2018

1 reference

Use of somatostatin receptor ligands in obesity and diabetic complications

21 January 2018

1 reference

Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist.

21 January 2018

1 reference

Somatostatin analogs in the diagnosis and treatment of cancer

21 January 2018

1 reference

Clinical use of a growth hormone receptor antagonist in the treatment of acromegaly

21 January 2018

1 reference

Can growth hormone prevent aging?

21 January 2018

1 reference

Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial

21 January 2018

1 reference

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

21 January 2018

1 reference

The new life of a centenarian: signalling functions of NAD(P).

21 January 2018

1 reference

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition

21 January 2018

1 reference

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

21 January 2018

1 reference

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

21 January 2018

1 reference

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

21 January 2018

1 reference

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

1 reference

Extended life-span conferred by cotransporter gene mutations in Drosophila.

21 January 2018

1 reference

Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans

21 January 2018

1 reference

Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy

21 January 2018

1 reference

Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates

21 January 2018

1 reference

Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function

21 January 2018

1 reference

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

21 January 2018

1 reference

21 January 2018

1 reference

Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.

21 January 2018

1 reference

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway

21 January 2018

1 reference

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

21 January 2018

1 reference

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 January 2018

1 reference

Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway

21 January 2018

1 reference

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

1 reference

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

21 January 2018

1 reference

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

21 January 2018

1 reference

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

21 January 2018

1 reference

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

21 January 2018

1 reference

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span

21 January 2018

1 reference

Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

1 reference

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

21 January 2018

1 reference

Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.

21 January 2018

1 reference

Chaperoning extended life.

21 January 2018

1 reference

JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila

21 January 2018

1 reference

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

21 January 2018

The genetics of aging

1 reference

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.

21 January 2018

1 reference

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

21 January 2018

1 reference

Unique lipoprotein phenotype and genotype associated with exceptional longevity

21 January 2018

1 reference

Biological evidence for inheritance of exceptional longevity

21 January 2018

1 reference

Genetic associations with human longevity at the APOE and ACE loci.

21 January 2018

1 reference

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

21 January 2018

1 reference

Adiposity as Compared with Physical Activity in Predicting Mortality among Women

21 January 2018

1 reference

Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study

21 January 2018

1 reference

The influence of amount of food on the reproduction rate and longevity of a sectarian. (Tokophyra infusionum)

31 March 2020

1 reference

Aging in rhesus monkeys: relevance to human health interventions

31 March 2020

1 reference

Calorie restriction and aging: review of the literature and implications for studies in humans

31 March 2020

1 reference

Calorie restriction in obesity: prevention of kidney disease in rodents

31 March 2020

1 reference

Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice

31 March 2020

1 reference

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

31 March 2020

1 reference

Syndrome X and mortality: a population-based study. Risk Factor and Life Expectancy Research Group

31 March 2020

1 reference

Insulin resistance in aging is related to abdominal obesity

31 March 2020

1 reference

Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients

31 March 2020

1 reference

The effects of weight loss treatments on upper and lower body fat

31 March 2020

1 reference

Sonographic assessment of changes in thickness of different abdominal fat layers in response to diet in obese women

31 March 2020

1 reference

31 March 2020

1 reference

A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding

31 March 2020

1 reference

Endogenous adipocyte precursor cells for regenerative soft-tissue engineering

31 March 2020

1 reference

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

31 March 2020

1 reference

Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse.

31 March 2020

1 reference

31 March 2020

Growth hormone and aging

1 reference

Somatostatin analogues as drug therapies for retinopathies.

31 March 2020

1 reference

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

31 March 2020

1 reference

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

31 March 2020

1 reference

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress

31 March 2020

1 reference

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

31 March 2020

1 reference

7 January 2021

Immune function and survival in a long-lived mouse strain subjected to undernutrition

1 reference

7 January 2021

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

7 January 2021

Lithium and weight gain

1 reference

7 January 2021

Identifiers

DOI

10.1038/NRD1777

1 reference

12 August 2017

1 reference

PubMed ID

15976816