(Q36227567)

12 August 2017

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title

Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene (English)

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12 August 2017

Melvin E Andersen

4

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author name string

Harvey J Clewell

series ordinal

1

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12 August 2017

P Robinan Gentry

series ordinal

2

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12 August 2017

Janet E Kester

series ordinal

3

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12 August 2017

language of work or name

English

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publication date

1 June 2005

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Critical Reviews in Toxicology

12 August 2017

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12 August 2017

35

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12 August 2017

413-433

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12 August 2017

5

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Risk assessment extrapolations and physiological modeling.

12 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Incorporating biological information in quantitative risk assessment: an example with methylene chloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Applying simulation modeling to problems in toxicology and risk assessment--a short perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

A physiologically based pharmacokinetic model for trichloroethylene in the male long-evans rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Use of tissue disposition data from rats and dogs to determine species differences in input parameters for a physiological model for perchloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Development of a physiologically based pharmacokinetic model for perchloroethylene using tissue concentration-time data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

The application of physiologically based pharmacokinetic modelling in the analysis of occupational exposure to perchloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Uncertainties in pharmacokinetic modeling for perchloroethylene: II. Comparison of model predictions with data for a variety of different parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Uncertainties in pharmacokinetic modeling for perchloroethylene. I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Evaluation of uncertainty in input parameters to pharmacokinetic models and the resulting uncertainty in output

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Cancer risk and tetrachloroethylene-contaminated drinking water in Massachusetts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Drinking Water Contamination and the Incidence of Leukemia and Non-Hodgkin's Lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Mortality in dry-cleaning workers: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Cancer in relation to occupational exposure to perchloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

A critical review of epidemiology studies of trichloroethylene and perchloroethylene and risk of renal-cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Critical review of the epidemiological literature on occupational exposure to perchloroethylene and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: A case study using alkyl phthalates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

The role of trichloracetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Glutathione conjugation of perchloroethene in subcellular fractions from rodent and human liver and kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Immunohistochemical localization of trichloroacylated protein adducts in tetrachloroethene-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Protective role of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced alterations in ATPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Peroxisome proliferator-activated receptors in inflammation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Physiologically based pharmacokinetic models for the transport of trichloroethylene in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Kinetics of tetrachloroethylene in volunteers; influence of exposure concentration and work load

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

ABSORPTION OF CARBON TETRACHLORIDE, TRICHLOROETHYLENE, TETRACHLOROETHYLENE, METHYLENE CHLORIDE, AND 1,1,1-TRICHLOROETHANE THROUGH THE HUMAN SKIN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Metabolic disposition study of chlorinated hydrocarbons in rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Physiological parameter values for physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Plasma binding of trichloroacetic acid in mice, rats, and humans under cancer bioassay and environmental exposure conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

The impact of exercise and intersubject variability on dose estimates for dichloromethane derived from a physiologically based pharmacokinetic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Human Kidney Methoxyflurane and Sevoflurane Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Factors affecting species differences in the kinetics of metabolites of trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Pharmacokinetics of tetrachloroethylene*1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

Population toxicokinetics of tetrachloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440590931994

10.1080/10408440590931994

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference