(Q35961038)

11 August 2017

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title

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene (English)

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11 August 2017

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Melvin E Andersen

2

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Harvey J Clewell

series ordinal

1

object named as

Harvey J Clewell

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PubMed ID

15560567

11 August 2017

language of work or name

English

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publication date

1 September 2004

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Critical Reviews in Toxicology

11 August 2017

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11 August 2017

34

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11 August 2017

5

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11 August 2017

385-445

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A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene

11 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically based pharmacokinetic analyses of simple mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The impact of exercise and intersubject variability on dose estimates for dichloromethane derived from a physiologically based pharmacokinetic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Pharmacokinetics for regulatory risk analysis: the case of trichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dose-response analyses of the carcinogenic effects of trichloroethylene in experimental animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Variability of safe dose estimates when using complicated models of the carcinogenic process. A case study: methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Evaluation of uncertainty in input parameters to pharmacokinetic models and the resulting uncertainty in output

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Uncertainties in pharmacokinetic modeling for perchloroethylene. I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Modeling benzene pharmacokinetics across three sets of animal data: parametric sensitivity and risk implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Uncertainties in pharmacokinetic modeling for perchloroethylene: II. Comparison of model predictions with data for a variety of different parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Butylated hydroxyanisole mechanistic data and risk assessment: conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Saccharin mechanistic data and risk assessment: urine composition, enhanced cell proliferation, and tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and Pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Chemically induced proliferation of peroxisomes: implications for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Have animal data been used inappropriately to estimate risks to humans from environmental trichloroethylene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Probability model on the use of sentinel animal monitoring for arbovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Mortality among aircraft manufacturing workers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Exposure assessment for a large epidemiological study of aircraft manufacturing workers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Cancer incidence among Danish workers exposed to trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Urinary concentrations of trichloroacetic acid in Danish workers exposed to trichloroethylene, 1947-1985.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The a posteriori probability of a kidney cancer cluster attributed to trichloroethylene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Renal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, Germany

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Renal cell cancer correlated with occupational exposure to trichloroethene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Inhalation carcinogenicity of trichloroethylene in mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The pharmacokinetics and macromolecular interactions of trichloroethylene in mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Pharmacokinetics of trichloroethylene in volunteers, influence of workload and exposure concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Effects of oral exposure to trichloroethylene on female reproductive function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolism, toxicity, and carcinogenicity of trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolism of trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Chlorinated ethylenes: their metabolism and effect on DNA repair in rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Three forms of trichloroethylene-metabolizing enzymes in rat liver induced by ethanol, phenobarbital, and 3-methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolism of trichloroethylene in man. II. Pharmacokinetics of metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Incorporation of pharmacokinetic and pharmacodynamic data into risk assessments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dose-response relationship for trichloroethylene in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Factors affecting species differences in the kinetics of metabolites of trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Species differences in response to trichloroethylene. II. Biotransformation in rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Consideration of the evidence for mechanisms of 1,1,2-trichloroethylene metabolism, including new identification of its dichloroacetic acid and trichloroacetic acid metabolites in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Chloroethylenes: a mechanistic approach to human risk evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Induction of strand breaks in DNA by trichloroethylene and metabolites in rat and mouse liver in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Early induction of reparative hyperplasia in the liver of B6C3F1 mice treated with dichloroacetate and trichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Trichloroacetic acid: studies on uptake and effects on hepatic DNA and liver growth in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and a human cell line by chlorinated acetic acids and chlorinated acetaldehydes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dichloroacetic acid and related compounds: induction of prophage in E. coli and mutagenicity and mutation spectra in Salmonella TA100.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Absence of mutagenic effects of sodium dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic end points

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Carcinogenic and mutagenic properties of chemicals in drinking water

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The role of regenerative cell proliferation in chloroform-induced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolic disposition study of chlorinated hydrocarbons in rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

In-vitro spin-trapping of free radicals produced during trichloroethylene and diethylether metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Toxicity and metabolism of trichloroethylene in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Morphological and biochemical analyses of trichloroethylene hepatotoxicity: differences in ethanol- and phenobarbital-pretreated rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Adduction of hemoglobin and albumin in vivo by metabolites of trichloroethylene, trichloroacetate, and dichloroacetate in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Ethanol toxicity and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Differing hepatotoxicity and lethality after subacute trichloroethylene exposure in aqueous or corn oil gavage vehicles in B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Three industrial solvents investigated for tumor promoting activity in the rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: possible relevance to species differences in hepatocarcinogenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Species differences in carcinogenicity: the role of metabolism in human risk evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Effect of cadmium on F-actin and microtubules of Madin-Darby canine kidney cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Hepatic peroxisome proliferation in rodents and its significance for humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The pharmacology of dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dioxin hepatic carcinogenesis: biologically motivated modeling and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Negative selection in hepatic tumor promotion in relation to cancer risk assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Liver fatty acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dose-response relationships of hepatic acyl-CoA oxidase and catalase activity and liver mitogenesis induced by the peroxisome proliferator ciprofibrate in C57BL/6N and BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

TGF alpha differentially expressed in liver foci induced by diethylnitrosamine initiation and peroxisome proliferator promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Carcinogenicity of chloral hydrate administered in drinking water to the male F344/N rat and male B6C3F1 mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Trichloroethylene-induced mouse lung tumors: studies of the mode of action and comparisons between species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Studies on the mechanism of nephrotoxicity and nephrocarcinogenicity of halogenated alkenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Potential role of alpha-2 mu-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Pathological excretion patterns of urinary proteins in renal cell cancer patients exposed to trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Biologically motivated computational modeling of chloroform cytolethality and regenerative cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The effect of environmental factors on the pharmacokinetic behaviour of organic solvent vapours

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic recirculation of major metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Statistical analysis of Clewell et al. PBPK model of trichloroethylene kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

A new method for determining allowable daily intakes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: implications for chloroform carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Carcinogenicity study of trichloroethylene, with and without epoxide stabilizers, in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440490500795

10.1080/10408440490500795

21 January 2018

Identifiers

DOI

1 reference

11 August 2017

1 reference

PubMed ID

15560567