(Q36241231)

13 August 2017

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title

Deregulated TGF-beta signaling in leukemogenesis (English)

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13 August 2017

3

Pier Paolo Pandolfi

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author name string

Hui-Kuan Lin

series ordinal

1

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13 August 2017

Stephan Bergmann

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 August 2005

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13 August 2017

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13 August 2017

24

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13 August 2017

5693-5700

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13 August 2017

37

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208923

13 August 2017

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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Loss of the tumor suppressor PML in human cancers of multiple histologic origins

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TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2

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Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1/ETO leukemia-associated fusion protein

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Membrane rafts and signaling by the multichain immune recognition receptors

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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

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Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element

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Role of promyelocytic leukemia (PML) protein in tumor suppression

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Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

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Cytokine signaling: STATS in plasma membrane rafts

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

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Loss of Smad3 in acute T-cell lymphoblastic leukemia.

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The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

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7 January 2021

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

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TGF-beta signaling in tumor suppression and cancer progression

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival.

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The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

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Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis

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Smad6 inhibits signalling by the TGF-beta superfamily.

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The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling

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PML protein isoforms and the RBCC/TRIM motif

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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Transforming growth factor-beta signaling in normal and malignant hematopoiesis

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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro

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Cell biology: an unexpected social servant

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Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML.

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Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

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7 January 2021

Cytoplasmic PML function in TGF-beta signalling

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7 January 2021

Ski/Sno and TGF-beta signaling.

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7 January 2021

Snail family members and cell survival in physiological and pathological cleft palates

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7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

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7 January 2021

Molecular mechanisms of leukemogenesis by AML1/EVI-1.

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7 January 2021

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

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7 January 2021

Acute promyelocytic leukemia with marrow fibrosis at initial presentation: possible involvement of transforming growth factor-beta(1)

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7 January 2021

Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

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7 January 2021

Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia

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7 January 2021

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7 January 2021

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7 January 2021

Mechanisms underlying ubiquitination

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7 January 2021

Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.

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7 January 2021

The role of PML in tumor suppression

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7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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7 January 2021

Role of PML in cell growth and the retinoic acid pathway

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7 January 2021

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7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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7 January 2021

The transcriptional role of PML and the nuclear body

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208923

1 reference

Dimensions Publication ID

13 August 2017

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1 reference