(Q36248891)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Transcriptional functionality of germ line p53 mutants influences cancer phenotype (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

1

1 reference

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1 January 2020

Yari Ciribilli

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Paola Menichini

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

7

Lucio Luzzatto

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

Jennifer Jordan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

David M Umbach

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Michael A Resnick

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Alberto Inga

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Gilberto Fronza

9

1 reference

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1 January 2020

language of work or name

English

0 references

publication date

1 July 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

published in

Clinical Cancer Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

13

1 reference

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1 January 2020

issue

13

1 reference

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1 January 2020

page(s)

3789-3795

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

1 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

p53 mutation heterogeneity in cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

The p53 pathway: positive and negative feedback loops

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

1 October 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

A cancer family syndrome in twenty-four kindreds

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

The IARC TP53 database: new online mutation analysis and recommendations to users

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128783

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

5 December 2018

1 reference

12 December 2020

Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

12 December 2020

Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s

1 reference

12 December 2020

The UMD TP53 database and website: update and revisions

1 reference

12 December 2020

Generation or birth cohort effect on cancer risk in Li-Fraumeni syndrome

1 reference

12 December 2020

p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements

1 reference

12 December 2020

10.1158/1078-0432.CCR-06-2545

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17606709%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference