(Q45876572)

English

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

scientific article published in January 2001

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scholarly article

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay (English)

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

author name string

Inga A

1

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

Monti P

2

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

Fronza G

3

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

Darden T

4

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

Resnick MA

5

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

language of work or name

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publication date

1 January 2001

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

20

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

501-513

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

4

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204116

0 references

p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

1 reference

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Dominant-negative p53 mutations selected in yeast hit cancer hot spots

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Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

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Thermodynamic stability of wild-type and mutant p53 core domain

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

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A simple p53 functional assay for screening cell lines, blood, and tumors

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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Use of transcription reporters with novel p53 binding sites to target tumour cells expressing endogenous or virally transduced p53 mutants with altered sequence-specificity

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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

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Twenty years of p53 research: structural and functional aspects of the p53 protein

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p53 DNA binding can be modulated by factors that alter the conformational equilibrium

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Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

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Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

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A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2.

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Regulation of the p53 tumor suppressor protein

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Increased apoptosis induction by 121F mutant p53

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Mammalian p53 can function as a transcription factor in yeast

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Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

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Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

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Structural aspects of the p53 protein in relation to gene evolution: a second look.

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

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Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein.

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Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

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Identifiers

10.1038/SJ.ONC.1204116

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

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0 references

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11313981

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