(Q36249883)

13 August 2017

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title

Therapeutic potential of peptide deformylase inhibitors (English)

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13 August 2017

Chen D

1

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13 August 2017

Yuan Z

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 September 2005

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Expert Opinion on Investigational Drugs

13 August 2017

published in

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13 August 2017

volume

14

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13 August 2017

issue

9

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13 August 2017

page(s)

1107-1116

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Erythromycin-resistant group A streptococci in schoolchildren in Pittsburgh

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents

21 January 2018

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Deformylase as a novel antibacterial target.

21 January 2018

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Inhibitors of protein synthesis

21 January 2018

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A survey of polypeptide deformylase function throughout the eubacterial lineage.

21 January 2018

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N-formylmethionyl-sRNA as the initiator of protein synthesis

21 January 2018

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On the release of the formyl group from nascent protein

21 January 2018

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Methionine as translation start signal: a review of the enzymes of the pathway in Escherichia coli.

21 January 2018

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Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site

21 January 2018

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Control of peptide deformylase activity by metal cations

21 January 2018

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Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene

21 January 2018

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Formylation is not essential for initiation of protein synthesis in all eubacteria.

21 January 2018

1 reference

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Characterization of an eukaryotic peptide deformylase from Plasmodium falciparum

21 January 2018

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Characterization of a human peptide deformylase: implications for antibacterial drug design

21 January 2018

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A new human peptide deformylase inhibitable by actinonin.

21 January 2018

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An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway

21 January 2018

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A new subclass of the zinc metalloproteases superfamily revealed by the solution structure of peptide deformylase

21 January 2018

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Crystal structure of the Escherichia coli peptide deformylase

21 January 2018

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Solution structure of nickel-peptide deformylase

21 January 2018

1 reference

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The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents

21 January 2018

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Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents

21 January 2018

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Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

21 January 2018

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N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity

21 January 2018

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Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

21 January 2018

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Mechanism of time-dependent inhibition of polypeptide deformylase by actinonin

21 January 2018

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In vitro activities of nine peptide deformylase inhibitors and five comparator agents against respiratory and skin pathogens

21 January 2018

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Antistaphylococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents

21 January 2018

1 reference

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Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents

21 January 2018

1 reference

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In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae

21 January 2018

1 reference

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Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Peptide deformylase as an antibacterial drug target: target validation and resistance development

21 January 2018

1 reference

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Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center

21 January 2018

1 reference

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Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Seeking new targets for antiparasitic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

The plastid-derived organelle of protozoan human parasites as a target of established and emerging drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.9.1107

10.1517/13543784.14.9.1107

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference