(Q36258853)

13 August 2017

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool (English)

1 reference

13 August 2017

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Meagan Sullender

3

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David E Root

6

object named as

David E Root

1 reference

13 August 2017

7

John G Doench

1 reference

13 August 2017

Katherine F Donovan

1

1 reference

13 August 2017

Mudra Hegde

2

1 reference

13 August 2017

Emma W Vaimberg

4

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13 August 2017

Cory M Johannessen

5

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13 August 2017

language of work or name

English

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publication date

24 January 2017

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13 August 2017

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13 August 2017

12

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13 August 2017

1

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13 August 2017

e0170445

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Creative Commons Attribution 4.0 International

13 August 2017

start time

24 January 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Massively parallel single-amino-acid mutagenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Saturation editing of genomic regions by multiplex homology-directed repair

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Deep mutational scanning: a new style of protein science

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Genome-scale CRISPR-Cas9 knockout screening in human cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Genetic screens in human cells using the CRISPR-Cas9 system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

A public genome-scale lentiviral expression library of human ORFs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

MEK1 mutations confer resistance to MEK and B-RAF inhibition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261743

10.1371/JOURNAL.PONE.0170445

22 September 2018

Identifiers

DOI

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13 August 2017

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1 reference

13 August 2017

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