(Q36286881)

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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

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Europe PubMed Central

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13 August 2017

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

apoptotic process

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Hagop Kantarjian

10

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Hagop Kantarjian

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Europe PubMed Central

PMC publication ID

13 August 2017

Marina Konopleva

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Marina Konopleva

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Europe PubMed Central

13 August 2017

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Michael Andreeff

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Michael Andreeff

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Europe PubMed Central

13 August 2017

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Steven M Kornblau

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Steven M Kornblau

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13 August 2017

12

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David A Fruman

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Europe PubMed Central

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13 August 2017

3

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Twee Tsao

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Europe PubMed Central

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13 August 2017

1

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Zhihong Zeng

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13 August 2017

4

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YiHua Qiu

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13 August 2017

author name string

Yue Xi Shi

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13 August 2017

Keith A Baggerly

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Europe PubMed Central

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13 August 2017

Wenbin Liu

7

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Europe PubMed Central

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13 August 2017

Katti Jessen

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Europe PubMed Central

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13 August 2017

Yi Liu

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13 August 2017

Christian Rommel

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13 August 2017

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publication date

23 July 2012

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Europe PubMed Central

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13 August 2017

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13 August 2017

120

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Europe PubMed Central

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13 August 2017

13

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Europe PubMed Central

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13 August 2017

2679-2689

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Europe PubMed Central

PMC publication ID

13 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3460689/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The translational landscape of mTOR signalling steers cancer initiation and metastasis

1 reference

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460689

30 September 2017

mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

1 reference

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The microenvironment in mantle cell lymphoma: cellular and molecular pathways and emerging targeted therapies

1 reference

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The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

1 reference

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30 September 2017

The bone marrow microenvironment and leukemia: biology and therapeutic targeting

1 reference

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30 September 2017

Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors

1 reference

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30 September 2017

Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.

1 reference

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30 September 2017

Leukemia stem cells and microenvironment: biology and therapeutic targeting

1 reference

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Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia.

1 reference

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30 September 2017

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

1 reference

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

1 reference

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30 September 2017

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

1 reference

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The nuts and bolts of AGC protein kinases

1 reference

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30 September 2017

Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches

1 reference

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30 September 2017

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

1 reference

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30 September 2017

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

1 reference

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30 September 2017

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

1 reference

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30 September 2017

Functional proteomic profiling of AML predicts response and survival

1 reference

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30 September 2017

HOX expression patterns identify a common signature for favorable AML.

1 reference

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Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia

1 reference

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

1 reference

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30 September 2017

Targeting the leukemia microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460689

30 September 2017

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

1 reference

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FLT3 mutations: biology and treatment

1 reference

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30 September 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

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PML-RARalpha is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival

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Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values

1 reference

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30 September 2017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

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A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

1 reference

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Multilineage potential of adult human mesenchymal stem cells

1 reference

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A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction.

1 reference

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30 September 2017

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

1 reference

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The pharmacology of mTOR inhibition

1 reference

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Non-parametric quantification of protein lysate arrays.

1 reference

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1 reference

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1 reference

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Targeted therapy of AML new concepts

1 reference

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Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

1 reference

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Mammalian target of rapamycin as a therapeutic target in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22826565

12 December 2020

based on heuristic

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Identifiers

10.1182/BLOOD-2011-11-393934

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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