(Q36289384)

13 August 2017

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title

Clinical pharmacokinetics of cyclophosphamide. (English)

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13 August 2017

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4

Jos H Beijnen

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13 August 2017

2

Alwin D R Huitema

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13 August 2017

Milly E de Jonge

1

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13 August 2017

Sjoerd Rodenhuis

series ordinal

3

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13 August 2017

publication date

1 January 2005

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Clinical Pharmacokinetics

13 August 2017

published in

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13 August 2017

volume

44

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13 August 2017

issue

11

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13 August 2017

page(s)

1135-1164

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https://scigraph.springernature.com/pub.10.2165/00003088-200544110-00003

13 August 2017

exact match

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cites work

The kinetics of salivary elimination of cyclophosphamide in man

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12 December 2020

Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation.

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12 December 2020

Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients

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12 December 2020

Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance

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12 December 2020

The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man

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12 December 2020

Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans

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12 December 2020

An overview of cyclophosphamide and ifosfamide pharmacology

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12 December 2020

Studies on the correlation between rate of biotransformation and haematological toxicity of cyclophosphamide

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12 December 2020

Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide

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12 December 2020

Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide.

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12 December 2020

Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide

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12 December 2020

Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children.

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12 December 2020

High-dose chemotherapy regimens for solid tumors

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12 December 2020

Alkylating properties of phosphoramide mustard

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12 December 2020

Clinical Pharmacokinetics of Cyclophosphamide

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12 December 2020

Bioactivation of cyclophosphamide: the role of polymorphic CYP2C enzymes

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12 December 2020

Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin

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12 December 2020

Enhanced transcription of the cytosolic ALDH gene in cyclophosphamide resistant human carcinoma cells

1 reference

12 December 2020

Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation

1 reference

12 December 2020

Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione

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12 December 2020

Preferential location of circulating activated cyclophosphamide within the erythrocyte

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12 December 2020

Effect of damaged liver parenchyma, renal insufficiency and hemodialysis on the pharmacokinetics of cyclophosphamide and its activated metabolites

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12 December 2020

Post-Cyclophosphamide Pneumonitis

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12 December 2020

Metabolism and pharmacokinetics of oxazaphosphorines

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12 December 2020

Analysis of cyclophosphamide and five metabolites from human plasma using liquid chromatography-mass spectrometry and gas chromatography-nitrogen-phosphorus detection

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12 December 2020

Pharmacokinetics of cyclophosphamide and its metabolites in bone marrow transplantation patients

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12 December 2020

Effect of liver failure on the pharmacokinetics of cyclophosphamide

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12 December 2020

The Biotransformation of Cyclophosphamide in Man: Analysis of the Variation in Normal Subjects

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12 December 2020

Cyclophosphamide (NSC-26271)-related phosphoramide mustards- recent advances and historical perspective

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12 December 2020

Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response

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12 December 2020

Pharmacokinetics of high-dose cyclophosphamide in patients with metastatic bronchogenic carcinoma

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12 December 2020

Comparative metabolism of 2-[bis(2-chloroethyl)amino]tetrahydro-2-H-1,3,2-oxazaphosphorine-2-oxide (cyclophosphamide) and its enantiomers in humans

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12 December 2020

Isolation and mass spectral identification of blood metabolities of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metabolite

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12 December 2020

Pharmacokinetics of cyclophosphamide (CP) and 4-OH-CP/aldophosphamide in systemic vasculitis

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12 December 2020

Decreased plasma half-life of cyclophosphamide during repeated high-dose administration

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12 December 2020

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices.

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12 December 2020

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

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12 December 2020

Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial

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12 December 2020

Plasma concentrations of 4-hydroxycyclophosphamide and phosphoramide mustard in patients repeatedly given high doses of cyclophosphamide in preparation for bone marrow transplantation

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12 December 2020

Pharmacokinetics and bioavailability of cyclophosphamide from oral formulations

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12 December 2020

What is the role of high-dose chemotherapy in the era of targeted therapies?

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12 December 2020

Cyclophosphamide metabolism in children following a 1-h and a 24-h infusion.

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12 December 2020

Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines

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12 December 2020

Effect of cyclophosphamide on advanced lung cancer and the hematological toxicity of large, intermittent intravenous doses

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12 December 2020

Repeated investigations of cyclophosphamide disposition in myeloma patients receiving intermittent chemotherapy

1 reference

12 December 2020

Studies on the in vivo formation of acrolein: 3-hydroxy-propylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation

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12 December 2020

Inhibition of carboxyethylphosphoramide mustard formation from 4-hydroxycyclophosphamide by carmustine

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12 December 2020

The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts

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12 December 2020

Studies on cyclophosphamide metabolites and their related compounds. I

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12 December 2020

Hepatic venoocclusive disease in autologous bone marrow transplantation of solid tumors and lymphomas

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12 December 2020

Population pharmacokinetics of cyclophosphamide, doxorubicin and etoposide in 30 patients with BEACOPP chemotherapy.

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12 December 2020

Activation of cyclophosphamide in man and animals

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12 December 2020

The enzymatic basis of cyclophosphamide specificity

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12 December 2020

Possible role of acrolein in 4-hydroperoxycyclophosphamide-induced cell damage in vitro

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12 December 2020

The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity

1 reference

12 December 2020

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.

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12 December 2020

Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide

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12 December 2020

Pharmacokinetics of cyclophosphamide in Kenyan African children with lymphoma

1 reference

12 December 2020

Cyclophosphamide and dimethylsulfoxide in the treatment of squamous carcinoma of the lung. Therapeutic efficacy, toxicity, and pharmacokinetics

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12 December 2020

31P nuclear magnetic resonance spectroscopic observation of the intracellular transformations of oncostatic cyclophosphamide metabolites

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12 December 2020

Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells

1 reference

12 December 2020

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide

1 reference

12 December 2020

Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens

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12 December 2020

DNA damage and mutagenesis induced by nitrogen mustards

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12 December 2020

Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation

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12 December 2020

Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses

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12 December 2020

Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation

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12 December 2020

Urinary excretion of cyclophosphamide in humans, determined by phosphorus-31 nuclear magnetic resonance spectroscopy

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12 December 2020

Rapid development of enhanced clearance after high-dose cyclophosphamide

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12 December 2020

Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin

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12 December 2020

Hemorrhagic cystitis complicating bone marrow transplantation

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12 December 2020

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

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12 December 2020

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

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12 December 2020

Population pharmacokinetics of adjuvant cyclophosphamide, methotrexate and 5-fluorouracil (CMF).

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12 December 2020

Pharmacokinetics of alkylating agents.

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12 December 2020

Glutathione-associated enzymes in anticancer drug resistance.

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12 December 2020

Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels

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12 December 2020

Human CYP2B6: expression, inducibility and catalytic activities

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12 December 2020

A phase I study of SR-2508 and cyclophosphamide administered by intravenous injection

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12 December 2020

Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin

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12 December 2020

Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide

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12 December 2020

Phenobarbital effects on cyclophosphamide pharmacokinetics in man

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12 December 2020

Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency

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12 December 2020

The mechanism of activation of 4-hydroxycyclophosphamide

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12 December 2020

Kinetics of cyclophosphamide biotransformation in vivo

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12 December 2020

Cyclophosphamide and 4-Hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving high-dose cyclophosphamide chemotherapy

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12 December 2020

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients

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12 December 2020

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

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12 December 2020

The analysis of cyclophosphamide and its metabolites.

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12 December 2020

Pharmacokinetics and metabolism of cyclophosphamide in paediatric patients

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12 December 2020

Bioavailability of cyclophosphamide in the CMF regimen

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12 December 2020

Pharmacokinetics and metabolism of cyclophosphamide administered after total body irradiation of bone marrow transplant recipients

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12 December 2020

Liquid chromatography-tandem mass spectrometric quantitation of cyclophosphamide and its hydroxy metabolite in plasma and tissue for determination of tissue distribution

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12 December 2020

Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity

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12 December 2020

Pharmacokinetics of high-dose cyclophosphamide for bone marrow transplantation

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12 December 2020

Fractionated administration of high-dose cyclophosphamide: influence on dose-dependent changes in pharmacokinetics and metabolism

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12 December 2020

Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy

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12 December 2020

Denaturation of cytochrome P-450 by cyclophosphamide metabolites

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12 December 2020

DNA damage in cyclophosphamide-resistant tumor cells: the role of glutathione.

1 reference

12 December 2020

Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450

1 reference

12 December 2020

Pharmacokinetics of cyclophosphamide in man

1 reference

12 December 2020

Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients

1 reference

12 December 2020

Cyclophosphamide and related anticancer drugs

1 reference

12 December 2020

1 reference

12 December 2020

Clinical pharmacokinetics of cyclophosphamide and metabolites with and without SR-2508.

1 reference

12 December 2020

Variability in the pharmacokinetics of cyclophosphamide, methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer

1 reference

12 December 2020

Formation of the cytotoxic aldehyde acrolein during in vitro degradation of cyclophosphamide

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12 December 2020

Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide

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12 December 2020

PLasma half-life and urinary excretion of cyclophosphamide in children

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

Glutathione diminishes the anti-tumour activity of 4-hydroperoxycyclophosphamide by stabilising its spontaneous breakdown to alkylating metabolites

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12 December 2020

Activated oxazaphosphorines are transported predominantly by erythrocytes

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12 December 2020

Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia

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12 December 2020

The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo

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12 December 2020

4-Ketocyclophosphamide, a metabolite of cyclophosphamide. Formation, chemical and biological properties

1 reference

12 December 2020

Hepatotoxicity of cyclophosphamide in man: pharmacokinetic analysis

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12 December 2020

Dose escalation of cyclophosphamide in patients with breast cancer: consequences for pharmacokinetics and metabolism

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12 December 2020

Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients

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12 December 2020

Glutathione, glutathione S-transferase alpha and pi, and aldehyde dehydrogenase content in relationship to drug resistance in ovarian cancer

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12 December 2020

Combined thin-layer chromatography—photography—densitometry for the quantitation of cyclophosphamide and its four principal urinary metabolites

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12 December 2020

Repeated high-dose cyclophosphamide administration in bone marrow transplantation: exposure to activated metabolites

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12 December 2020

Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde

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12 December 2020

Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation.

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12 December 2020

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

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12 December 2020

Nonpredictable pharmacokinetic behavior of high-dose cyclophosphamide in combination with cisplatin and 1,3-bis(2-chloroethyl)-1-nitrosourea

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12 December 2020

Pharmacokinetics of cyclophosphamide and alkylating activity in man after intravenous and oral administration

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12 December 2020

Pharmacokinetics of 4-hydroxycyclophosphamide and metabolites in the rat

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12 December 2020

Association of high-dose cyclophosphamide, cisplatin, and carmustine pharmacokinetics with survival, toxicity, and dosing weight in patients with primary breast cancer.

1 reference

12 December 2020

The hepatotoxic action of allyl formate

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12 December 2020

Cyclophosphamide metabolism in children with Fanconi's anaemia

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12 December 2020

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospr

1 reference

12 December 2020

Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo

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12 December 2020

Cardiotoxicity Associated With High-Dose Cyclophosphamide Therapy

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12 December 2020

Molecular genetics of human aldehyde dehydrogenase

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12 December 2020

Effect of cyclophosphamide on gene expression of cytochromes p450 and beta-actin in the HL-60 cell line

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12 December 2020

Urological Complications of Cyclophosphamide

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12 December 2020

The Biotransformation of Cyclophosphamide in Man: Influence of Prednisone

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12 December 2020

Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers

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12 December 2020

[Studies on the spontaneous decomposition of 4-hydroxyphosphamide and 4-hydroperoxyphosphamide by means of thin-layer chromatography]

1 reference

12 December 2020

Therapeutic effects of single-push or fractionated injections or continuous infusion of oxazaphosphorines (cyclophosphamide, ifosfamide, Asta Z 7557)

1 reference

12 December 2020

Cyclophosphamide cardiotoxicity in bone marrow transplantation: a prospective evaluation of new dosing regimens

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12 December 2020

A limited sampling strategy for cyclophosphamide pharmacokinetics.

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12 December 2020

Aldehyde dehydrogenase-mediated cellular relative insensitivity to the oxazaphosphorines

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12 December 2020

Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide

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12 December 2020

Cyclophosphamide cystitis—Identification of acrolein as the causative agent

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12 December 2020

Hemorrhagic cystitis following high-dose chemotherapy and bone marrow transplantation in children with malignancies: incidence, clinical course, and outcome

1 reference

12 December 2020

Clinical pharmacology of cyclophosphamide

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12 December 2020

Mesna compared with continuous bladder irrigation as uroprotection during high-dose chemotherapy and transplantation: a randomized trial

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12 December 2020

The pharmacokinetics of cyclophosphamide, phosphoramide mustard and nor-nitrogen mustard studied by gas chromatography in patients receiving cyclophosphamide therapy

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12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

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12 December 2020

Pharmacokinetics of cyclophosphamide in Kenyan Africans

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12 December 2020

Determination of cyclophosphamide and its metabolites in human plasma by high-performance liquid chromatography-mass spectrometry

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12 December 2020

Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite

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12 December 2020

Clinical pharmacokinetics of cyclophosphamide

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12 December 2020

Glutathione S-transferase-pi expression and glutathione concentration in ovarian carcinoma before and after chemotherapy

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12 December 2020

Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide

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12 December 2020

Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor

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12 December 2020

Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3.

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12 December 2020

Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma

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12 December 2020

Cyclophosphamide pharmacokinetics in children

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12 December 2020

Pharmacokinetics of cyclophosphamide in patients with systemic necrotizing angiitis

1 reference

12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

1 reference

12 December 2020

Pharmacokinetic interaction between ondansetron and cyclophosphamide during high-dose chemotherapy for breast cancer

1 reference

12 December 2020

Modification of the pharmacokinetics of high-dose cyclophosphamide and cisplatin by antiemetics

1 reference

12 December 2020

Deoxyribonucleic acid crosslinking by 4-hydroperoxycyclophosphamide in cyclophosphamide-sensitive and -resistant L1210 cells

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12 December 2020

Lack of bone marrow toxicity of high-dose cyclophosphamide associated with inefficient drug metabolism

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12 December 2020

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes

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12 December 2020

Accelerated decomposition of 4-hydroxycyclophosphamide by human serum albumin.

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12 December 2020

Complications of cyclophosphamide therapy

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12 December 2020

Phase I trial with pharmacokinetic analyses of high-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow transplantation in patients with refractory germ cell tumors

1 reference

12 December 2020

Studies on the selective action of cyclophosphamide (NSC-26271): Inactivation of the hydroxylated metabolite by tissue-soluble enzymes

1 reference

12 December 2020

Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines

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12 December 2020

The disposition of cyclophosphamide in a group of myeloma patients

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12 December 2020

The effect of fluconazole on cyclophosphamide metabolism in children

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12 December 2020

Aldehyde dehydrogenase-catalyzed bioinactivation of cyclophosphamide

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12 December 2020

Risk factors in bone marrow transplant recipients with leukaemia. Increased relapse risk in patients treated with ciprofloxacin for gut decontamination

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12 December 2020

Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation

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12 December 2020

Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation

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12 December 2020

Cyclophosphamide toxicity. Characterising and avoiding the problem

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12 December 2020

Genetic and environmental factors affecting drug disposition in man

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12 December 2020

Cyclophosphamide metabolism in children

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12 December 2020

Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione.

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12 December 2020

Lack of relationship between systemic exposure for the component drug of the fluorouracil, epirubicin, and 4-hydroxycyclophosphamide regimen in breast cancer patients

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12 December 2020

Cyclophosphamide metabolism is affected by azole antifungals

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12 December 2020

Enantioselective induction of cyclophosphamide metabolism by phenytoin.

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12 December 2020

CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes

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12 December 2020

Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients

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12 December 2020

Pharmacokinetics of "activated" cyclophosphamide and therapeutic efficacies

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12 December 2020

Effect of renal insufficiency on the pharmacokinetics of cyclophosphamide and some of its metabolites

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12 December 2020

Mechanisms of resistance to the toxicity of cyclophosphamide

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12 December 2020

Role of glutathione in the in vitro synergism between 4-hydroperoxy-cyclophosphamide and cisplatin in leukemia cell lines

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12 December 2020

Metabolism of high doses of cyclophosphamide

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12 December 2020

Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes

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12 December 2020

Half-life of oxazaphosphorines in biological fluids

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12 December 2020

The partitioning of phosphoramide mustard and its aziridinium ions among alkylation and P-N bond hydrolysis reactions

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12 December 2020

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction

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12 December 2020

Chemotherapeutic action of a cyclic nitrogen mustard phosphamide ester (B 518-ASTA) in experimental tumours of the rat.

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12 December 2020

Carboxyphosphamide: NMR studies of its stability and cell membrane permeability

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12 December 2020

Pharmacokinetics of Cyclophosphamide in Renal Failure

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12 December 2020

The metabolism of cyclophosphamide. Dose dependency and the effect of long-term treatment with cyclophosphamide

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12 December 2020

NADPH-dependent enzyme-catalyzed reduction of aldophosphamide, the pivotal metabolite of cyclophosphamide

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12 December 2020

Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein

1 reference

12 December 2020

Phase I clinical and pharmacokinetic study of cyclophosphamide administered by five-day continuous intravenous infusion

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12 December 2020

Identification and quantification of metabolite conjugates of activated cyclophosphamide and ifosfamide with mesna in urine by ion-pair extraction and fast atom bombardment mass spectrometry.

1 reference

12 December 2020

Metabolism of oxazaphosphorines

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12 December 2020

Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease

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12 December 2020

Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes

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12 December 2020

Inhibition of rat liver glutathione S-transferase isoenzymes by acrolein

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12 December 2020

Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo

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12 December 2020

Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard

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12 December 2020

Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients

1 reference

12 December 2020

Decreased half life of cyclophosphamide in patients under continual treatment

1 reference

12 December 2020

10.2165/00003088-200544110-00003

Identifiers

DOI

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Dimensions Publication ID

13 August 2017

1004413641

0 references

1 reference