(Q36291605)

13 August 2017

1 reference

title

RNAi: a potential therapy for the dominantly inherited nucleotide repeat diseases (English)

1 reference

13 August 2017

Denovan-Wright EM

1

1 reference

13 August 2017

Davidson BL

series ordinal

2

1 reference

13 August 2017

publication date

1 March 2006

1 reference

13 August 2017

1 reference

13 August 2017

volume

13

1 reference

13 August 2017

issue

6

1 reference

13 August 2017

page(s)

525-531

1 reference

Genetic analysis of RNA-mediated transcriptional gene silencing.

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Small interfering RNA-induced transcriptional gene silencing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Dicers at RISC; the mechanism of RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

MicroRNA biogenesis: coordinated cropping and dicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Genes involved in hereditary ataxias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Pathogenic RNA repeats: an expanding role in genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Identification and characterization of the gene causing type 1 spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Polyglutamine expansion of huntingtin impairs its nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Transcriptional abnormalities in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Specific and potent RNAi in the nucleus of human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Local gene knockdown in the brain using viral-mediated RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-defici

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

The HIV Tat protein transduction domain improves the biodistribution of beta-glucuronidase expressed from recombinant viral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

RNA-directed DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Therapeutic effects of cystamine in a murine model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302664

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302664

1 reference

13 August 2017

1 reference