(Q36293304)

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Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization (English)

1 reference

Europe PubMed Central

13 August 2017

author name string

L Wei

1

1 reference

Europe PubMed Central

13 August 2017

Y Zhou

2

1 reference

Europe PubMed Central

13 August 2017

C Qiao

3

1 reference

Europe PubMed Central

13 August 2017

T Ni

4

1 reference

Europe PubMed Central

13 August 2017

Z Li

5

1 reference

Europe PubMed Central

13 August 2017

Q You

6

1 reference

Europe PubMed Central

13 August 2017

Q Guo

7

1 reference

Europe PubMed Central

13 August 2017

N Lu

8

1 reference

Europe PubMed Central

13 August 2017

publication date

9 April 2015

1 reference

Europe PubMed Central

13 August 2017

Cell Death and Disease

1 reference

Europe PubMed Central

13 August 2017

6

1 reference

Europe PubMed Central

13 August 2017

e1714

1 reference

Europe PubMed Central

13 August 2017

copyright license

Creative Commons Attribution 4.0 International

1 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.

1 reference

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30 September 2017

Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease

1 reference

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30 September 2017

Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.

1 reference

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30 September 2017

SIRT3 and cancer: tumor promoter or suppressor?

1 reference

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30 September 2017

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Hallmarks of Cancer: The Next Generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Forkhead homeobox type O transcription factors in the responses to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

HIF-1: upstream and downstream of cancer metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Mitochondrial reactive oxygen species regulate hypoxic signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Recent progress in the biology and physiology of sirtuins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Regulation of hexokinase binding to VDAC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

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30 September 2017

Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer

1 reference

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30 September 2017

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

1 reference

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30 September 2017

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

1 reference

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30 September 2017

Glucose metabolism and cancer

1 reference

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30 September 2017

Altered sirtuin expression is associated with node-positive breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650553

30 September 2017

Oncological implications of hypoxia inducible factor-1alpha (HIF-1alpha) expression

1 reference

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30 September 2017

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

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30 September 2017

Why do cancers have high aerobic glycolysis?

1 reference

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30 September 2017

Hydroxylation of HIF-1: oxygen sensing at the molecular level

1 reference

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30 September 2017

Hypoxia, HIF1 and glucose metabolism in the solid tumour

1 reference

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Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis

1 reference

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Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography

1 reference

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22 September 2018

Identifiers

10.1038/CDDIS.2015.86

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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