(Q36318799)

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Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species (English)

1 reference

Europe PubMed Central

13 August 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

3

object named as

JoAnne Stubbe

1 reference

Europe PubMed Central

13 August 2017

author name string

Yimon Aye

1

1 reference

Europe PubMed Central

13 August 2017

Marcus J C Long

2

1 reference

Europe PubMed Central

13 August 2017

language of work or name

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publication date

22 August 2012

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Europe PubMed Central

13 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

13 August 2017

287

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Europe PubMed Central

13 August 2017

42

1 reference

Europe PubMed Central

13 August 2017

35768-35778

1 reference

Europe PubMed Central

13 August 2017

Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers

1 reference

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Iron chelators for the treatment of cancer.

1 reference

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DNA building blocks: keeping control of manufacture

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30 September 2017

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study

1 reference

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30 September 2017

Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins

1 reference

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30 September 2017

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

1 reference

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30 September 2017

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

1 reference

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Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo.

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Function and biogenesis of iron-sulphur proteins

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Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

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Species-specific differences in translational regulation of dihydrofolate reductase

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A phase II trial of triapine (NSC# 663249) and gemcitabine as second line treatment of advanced non-small cell lung cancer: Eastern Cooperative Oncology Group Study 1503

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2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

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Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine

1 reference

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30 September 2017

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.

1 reference

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30 September 2017

Chelators at the cancer coalface: desferrioxamine to Triapine and beyond.

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Ribonucleotide reductase inhibitors and future drug design

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Ribonucleotide reductase modularity: Atypical duplication of the ATP-cone domain in Pseudomonas aeruginosa

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Ribonucleotide reductases

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A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase

1 reference

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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells

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Balancing acts: molecular control of mammalian iron metabolism

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Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer?

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The DNA damage response: putting checkpoints in perspective

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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

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Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells

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Assay of metabolic superoxide production in Escherichia coli

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Activation of the iron-containing B2 protein of ribonucleotide reductase by hydrogen peroxide

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Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction

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Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators

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The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase

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Identifiers

10.1074/JBC.M112.396911

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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