(Q36321788)

13 August 2017

Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway (English)

1 reference

13 August 2017

1 reference

1 reference

Chung Y Hsu

8

0 references

Jan Xu

2

object named as

Jan Xu

1 reference

13 August 2017

3

Jin-Moo Lee

1 reference

13 August 2017

7

Shawei Chen

1 reference

13 August 2017

Jiunn-Tay Lee

1

1 reference

13 August 2017

Grace Ku

4

1 reference

13 August 2017

Xianlin Han

5

1 reference

13 August 2017

Ding-I Yang

6

1 reference

13 August 2017

language of work or name

English

0 references

publication date

1 January 2004

1 reference

13 August 2017

Journal of Cell Biology

1 reference

13 August 2017

164

1 reference

13 August 2017

1

1 reference

13 August 2017

123-131

1 reference

Protein measurement with the Folin phenol reagent

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Ceramide and sphingomyelinases in the regulation of stress responses

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Ceramide in the eukaryotic stress response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

The role of oxidative stress in Alzheimer disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Signalling sphingomyelinases: which, where, how and why?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Mechanism of amyloid beta protein induced neuronal cell death: current concepts and future perspectives.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Sphingomyelin breakdown and cell fate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Effects of Ara-C on neutral sphingomyelinase and mitogen- and stress-activated protein kinases in T-lymphocyte cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Functions of ceramide in coordinating cellular responses to stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Sphingolipid metabolism and cell growth regulation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Oxidative stress and mitochondrial dysfunction in neurodegeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Protein kinase cascades activated by stress and inflammatory cytokines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

The effect of glutathione depletion by diamide, diethyl maleate or buthione sulfoximine on the surface structure of mouse L-cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Regulation of ceramide production and apoptosis

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Melatonin protects bovine cerebral endothelial cells from hyperoxia-induced DNA damage and death.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Oxidative stress after acute and chronic application of beta-amyloid fragment 25-35 in cortical cultures

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Hydrogen peroxide mediates amyloid beta protein toxicity

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Interaction of sphingomyelinase with sphingomyelin analogs modified at the C-1 and C-3 positions of the sphingosine backbone.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Amyloid beta-peptide is produced by cultured cells during normal metabolism

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress.

29 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Amyloid beta-peptide possesses a transforming growth factor-beta activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Induction of oligodendrocyte apoptosis by C2-ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Influence of diethylmaleate on the formation of bis(methylmercuric)selenide and methylmercury distribution in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Amyloid-beta peptides are cytotoxic to oligodendrocytes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

The amyloid beta protein induces oxidative damage of mitochondrial DNA.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171973

Redox regulation of fos and jun DNA-binding activity in vitro

22 September 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-in

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200307017

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14709545

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14709545

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200307017

1 reference

13 August 2017

1 reference

13 August 2017

1 reference