(Q36332669)

13 August 2017

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title

The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors (English)

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13 August 2017

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Paul S Aisen

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13 August 2017

publication date

1 January 2005

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13 August 2017

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13 August 2017

volume

19

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13 August 2017

issue

12

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13 August 2017

page(s)

989-996

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

13 August 2017

cites work

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12 December 2020

Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation

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12 December 2020

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

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12 December 2020

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Alzheimer's disease. New insights into its cause lead to new drug strategies

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12 December 2020

Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

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12 December 2020

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

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12 December 2020

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

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12 December 2020

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

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12 December 2020

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

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12 December 2020

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

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12 December 2020

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12 December 2020

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

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12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

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12 December 2020

Gleevec inhibits β-amyloid production but not Notch cleavage

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

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12 December 2020

The metallobiology of Alzheimer's disease

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12 December 2020

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization

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12 December 2020

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

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12 December 2020

Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?

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12 December 2020

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

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12 December 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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12 December 2020

A very incomplete comprehensive theory of Alzheimer's disease

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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12 December 2020

Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells

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12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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12 December 2020

Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals

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12 December 2020

Memantine in moderate-to-severe Alzheimer's disease

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

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12 December 2020

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides

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12 December 2020

Glycosaminoglycan mimetics: a therapeutic approach to cerebral amyloid angiopathy

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12 December 2020

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway

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12 December 2020

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

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12 December 2020

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Peptide inhibitors of beta amyloid aggregation

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12 December 2020

Alzheimer Neurofibrillary Degeneration: Therapeutic Targets and High-Throughput Assays

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12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

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12 December 2020

Strategies for disease modification in Alzheimer's disease

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12 December 2020

Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia

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12 December 2020

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

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12 December 2020

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

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12 December 2020

10.2165/00023210-200519120-00002

Identifiers

DOI

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Dimensions Publication ID

13 August 2017

1019421153

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