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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.
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Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
title
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
main subject
cell death
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based on heuristic
inferred from title
author
Haigang Ren
series ordinal
1
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Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
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11 February 2020
author name string
Kai Fu
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2
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Europe PubMed Central
PMC publication ID
3479024
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
Chenchen Mu
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3
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Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
Xuechu Zhen
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4
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3479024
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retrieved
11 February 2020
Guanghui Wang
series ordinal
5
1 reference
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Europe PubMed Central
PMC publication ID
3479024
reference URL
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retrieved
11 February 2020
publication date
14 August 2012
1 reference
stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
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retrieved
11 February 2020
published in
Molecular Neurodegeneration
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stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
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retrieved
11 February 2020
volume
7
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Europe PubMed Central
PMC publication ID
3479024
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retrieved
11 February 2020
page(s)
40
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stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
cites work
Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Recent advances in the genetics of Parkinson's disease
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PubMed Central
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30 September 2017
Mitochondria and programmed cell death in Parkinson's disease: apoptosis and beyond
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30 September 2017
DJ-1 regulation of mitochondrial function and autophagy through oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Mitochondrial dysfunction in neurodegenerative diseases and cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
DJ-1, PINK1, and their effects on mitochondrial pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Mitochondrial dynamics in Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Bcl-XL protein is markedly decreased in UVB-irradiated basal cell carcinoma cell lines through proteasome-mediated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
The BCL-2 protein family: opposing activities that mediate cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
DJ-1: a newcomer in Parkinson's disease pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
DJ-1 decreases Bax expression through repressing p53 transcriptional activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Bcl-xL and bcl-2 proteins in melanoma progression and UVB-induced apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
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30 September 2017
Molecular pathophysiology of Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
DJ-1 has a role in antioxidative stress to prevent cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Targeting programmed cell death in neurodegenerative diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
30 September 2017
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
29 June 2018
DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
22 September 2018
p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
22 September 2018
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
22 September 2018
The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
22 September 2018
Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479024
retrieved
22 September 2018
Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22892098
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mitochondrial dysfunction in Parkinson's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22892098
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22892098
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/1750-1326-7-40
1 reference
stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
Dimensions Publication ID
1003247857
0 references
PMC publication ID
3479024
1 reference
stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
PubMed publication ID
22892098
1 reference
stated in
Europe PubMed Central
PMC publication ID
3479024
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22892098%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 February 2020
ResearchGate publication ID
230670537
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