(Q37764793)

22 August 2017

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title

Mitochondrial dysfunction in neurodegenerative diseases and cancer (English)

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22 August 2017

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Michelle Barbi de Moura

series ordinal

1

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22 August 2017

Lucas Santana dos Santos

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2

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22 August 2017

Bennett Van Houten

series ordinal

3

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22 August 2017

publication date

1 June 2010

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Environmental and Molecular Mutagenesis

22 August 2017

published in

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22 August 2017

volume

51

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22 August 2017

issue

5

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22 August 2017

page(s)

391-405

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Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

22 August 2017

cites work

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The cellular production of hydrogen peroxide

21 January 2018

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A hierarchy of ATP-consuming processes in mammalian cells

21 January 2018

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Mitochondria in Huntington's disease

21 January 2018

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

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Mitochondrial DNA repair and aging

21 January 2018

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The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

21 January 2018

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Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study

21 January 2018

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Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease

21 January 2018

1 reference

7 January 2021

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics

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7 January 2021

Human mitochondrial DNA is packaged with TFAM.

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7 January 2021

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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7 January 2021

The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.

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7 January 2021

Advances in the understanding of early Huntington's disease using the functional imaging techniques of PET and SPET.

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7 January 2021

Presenilin-1 is located in rat mitochondria

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7 January 2021

Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells

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7 January 2021

Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells

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7 January 2021

Mitochondrial alterations in Alzheimer's disease

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7 January 2021

Analysis of the IDH1 codon 132 mutation in brain tumors

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7 January 2021

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression

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7 January 2021

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

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7 January 2021

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

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7 January 2021

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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7 January 2021

p53: new roles in metabolism

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7 January 2021

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

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7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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7 January 2021

Mitochondrial mutations in cancer

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7 January 2021

Regional mitochondrial respiratory activity in Huntington's disease brain

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7 January 2021

Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

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7 January 2021

Succinate dehydrogenase deficiency in human

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7 January 2021

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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7 January 2021

3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

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7 January 2021

Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models

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7 January 2021

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

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7 January 2021

Mitochondrial defects in cancer

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7 January 2021

Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27

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7 January 2021

The organization and inheritance of the mitochondrial genome

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7 January 2021

Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats

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7 January 2021

Mitochondrial DNA alterations in cancer.

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7 January 2021

The regulation of energy generating metabolic pathways by p53

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7 January 2021

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

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7 January 2021

Parkinson's disease and cancer: insights for pathogenesis from epidemiology .

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7 January 2021

Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas

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7 January 2021

Evidence of oxidative stress in the neocortex in incidental Lewy body disease

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7 January 2021

Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer.

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7 January 2021

Is cancer a disease of abnormal cellular metabolism? New angles on an old idea

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7 January 2021

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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7 January 2021

Brick by brick: metabolism and tumor cell growth

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7 January 2021

Mitochondrial disorders in the nervous system

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7 January 2021

A Prospective Cohort Study of Cancer Incidence Following the Diagnosis of Parkinson's Disease

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7 January 2021

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

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7 January 2021

Mitochondrial transcription factor A regulates mtDNA copy number in mammals

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7 January 2021

Nonfatal cancer preceding Parkinson's disease: a case-control study

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7 January 2021

The contribution of mitochondria to common disorders

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7 January 2021

HIF, a missing link between metabolism and cancer

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7 January 2021

Crosstalk signaling between mitochondrial Ca2+ and ROS.

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7 January 2021

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

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7 January 2021

Mitochondria in cancer: not just innocent bystanders

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7 January 2021

alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity

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7 January 2021

Parkin as a tumor suppressor gene for hepatocellular carcinoma

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7 January 2021

Energy boost: the Warburg effect returns in a new theory of cancer

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7 January 2021

Life's smile, death's grin: vital functions of apoptosis-executing proteins

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7 January 2021

Composition and dynamics of human mitochondrial nucleoids

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7 January 2021

Molecular pathogenesis of Parkinson disease: insights from genetic studies

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7 January 2021

Diseases of unstable repeat expansion: mechanisms and common principles

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7 January 2021

Targeting the progression of Parkinson's disease.

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7 January 2021

Mitochondrial DNA nucleoids determine mitochondrial genetics and dysfunction

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7 January 2021

Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

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7 January 2021

Mitochondria as targets for chemotherapy

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7 January 2021

Mitochondrial tumour suppressors: a genetic and biochemical update

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7 January 2021

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

Mitochondrial defect in Huntington's disease caudate nucleus

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7 January 2021

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

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7 January 2021

Genetics of Parkinson's disease and parkinsonism

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7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

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7 January 2021

Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis

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7 January 2021

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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7 January 2021

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

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7 January 2021

Cancer cell metabolism: Warburg and beyond

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7 January 2021

Huntington's disease: from pathology and genetics to potential therapies

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7 January 2021

The role of the electron transport gene SDHC on lifespan and cancer

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7 January 2021

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

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7 January 2021

Alzheimer's disease: from pathology to therapeutic approaches

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7 January 2021

Recent advances in our understanding of neurodegeneration

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7 January 2021

The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction

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7 January 2021

Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA

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7 January 2021

The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures

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7 January 2021

Dementia: the bare essentials

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7 January 2021

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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7 January 2021

Evolutionary tinkering with mitochondrial nucleoids

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7 January 2021

Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease.

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7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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7 January 2021

The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?

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7 January 2021

Organization and dynamics of human mitochondrial DNA.

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7 January 2021

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

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7 January 2021

Iron-sulfur-protein biogenesis in eukaryotes

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7 January 2021

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

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7 January 2021

Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy

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7 January 2021

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

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7 January 2021

Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids

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7 January 2021

3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells

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7 January 2021

A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases

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7 January 2021

Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond

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7 January 2021

AKT/PKB signaling: navigating downstream

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7 January 2021

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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7 January 2021

p53 regulates mitochondrial respiration

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7 January 2021

The role of hypoxia-inducible factors in cancer

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7 January 2021

Mitochondria: more than just a powerhouse

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7 January 2021

The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species.

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7 January 2021

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

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7 January 2021

How mitochondria produce reactive oxygen species

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7 January 2021

Huntington's disease genetics

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7 January 2021

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival

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7 January 2021

Glucose avidity of carcinomas.

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7 January 2021

Mitochondria, oxidative stress and cell death

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7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 January 2021

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

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7 January 2021

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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7 January 2021

Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi

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7 January 2021

An integrated genomic analysis of human glioblastoma multiforme

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7 January 2021

Tumor Mitochondria and the Bioenergetics of Cancer Cells

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7 January 2021

Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen

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7 January 2021

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

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7 January 2021

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

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7 January 2021

Akt-dependent transformation: there is more to growth than just surviving

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7 January 2021

Somatic mutations of the mitochondrial genome in human colorectal tumours

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7 January 2021

The PINK1/Parkin pathway regulates mitochondrial morphology

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7 January 2021

c-Myc: linking transformation and genomic instability

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7 January 2021

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

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7 January 2021

Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease

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7 January 2021

Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis

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7 January 2021

p53 and disease: when the guardian angel fails

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7 January 2021

Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway

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7 January 2021

Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death

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7 January 2021

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

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7 January 2021

Mitochondrial dysfunction in neurodegenerative diseases.

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7 January 2021

ROS, mitochondria and the regulation of autophagy

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7 January 2021

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

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7 January 2021

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

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7 January 2021

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

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7 January 2021

Role of Akt signaling in vascular homeostasis and angiogenesis

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7 January 2021

Topology of superoxide production from different sites in the mitochondrial electron transport chain

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7 January 2021

A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease

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7 January 2021

The Alzheimer's disease mitochondrial cascade hypothesis: an update

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7 January 2021

Metabolic enzymes as oncogenes or tumor suppressors

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7 January 2021

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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7 January 2021

Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

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7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

Role of mitochondrial DNA in toxic responses to oxidative stress

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7 January 2021

Targeting programmed cell death in neurodegenerative diseases

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7 January 2021

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7 January 2021

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

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7 January 2021

On the Origin of Cancer Cells

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7 January 2021

Mitochondrial dysfunction in Parkinson's disease

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7 January 2021

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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7 January 2021

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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7 January 2021

IDH1 and IDH2 mutations in gliomas

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7 January 2021

Cell death pathways in Parkinson's disease: role of mitochondria

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7 January 2021

Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer

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7 January 2021

Sugar and fat - that's where it's at: metabolic changes in tumors

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7 January 2021

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

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7 January 2021

Parkinson's disease and cancer

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7 January 2021

Mitochondrial DNA mutations in cancer

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7 January 2021

Identifiers

DOI

10.1002/EM.20575

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22 August 2017

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