(Q36341660)

English

Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

1 reference

Europe PubMed Central

Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Elizabeth C M de Lange

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Paulien G M Ravenstijn

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Dorien Groenendaal

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Tamara J van Steeg

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

7 October 2005

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

The AAPS Journal

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Europe PubMed Central

PMC publication ID

13 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

E532-43

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

describes a project that uses

1 reference

based on heuristic

inferred from title

Potential role of drug transporters in the pathogenesis of medically intractable epilepsy

1 reference

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Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human Epilepsy

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

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The cell biology of the blood-brain barrier.

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BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.

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Transgenic animals as models in the study of the neurobiological role of polyamines

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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MDR1 gene expression in brain of patients with medically intractable epilepsy

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30 September 2017

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.

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Recent advances in blood-brain barrier transport

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29 June 2018

Operational models of pharmacological agonism.

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Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Active transport of fentanyl by the blood-brain barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Drug-protein binding and blood-brain barrier permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751256

22 September 2018

Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-based pharmacokinetic-pharmacodynamic analysis of corticosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the binding of isradipine and darodipine to different plasma proteins on their transfer through the rat blood-brain barrier. Drug binding to lipoproteins does not limit the transfer of drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16353931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1208/AAPSJ070354

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

0 references

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