(Q36353507)

13 August 2017

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title

Cell permeable iron chelators as potential cancer chemotherapeutic agents (English)

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13 August 2017

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Paula M B Pahl

1

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13 August 2017

Lawrence D Horwitz

series ordinal

2

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13 August 2017

publication date

1 January 2005

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13 August 2017

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13 August 2017

volume

23

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13 August 2017

issue

8

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13 August 2017

page(s)

683-691

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Transferrin receptor overexpression enhances transferrin responsiveness and the metastatic growth of a rat mammary adenocarcinoma cell line

13 August 2017

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Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells

21 January 2018

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Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

21 January 2018

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Reactive oxygen species in oncogenic transformation

21 January 2018

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p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

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Genetic regulation of cell function in response to iron overload or chelation.

21 January 2018

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Reactive oxygen species as intracellular messengers during cell growth and differentiation

21 January 2018

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Cytosolic Ca2+ movements of endothelial cells exposed to reactive oxygen intermediates: role of hydroxyl radical-mediated redox alteration of cell-membrane Ca2+ channels.

21 January 2018

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Iron and carcinogenesis: from Fenton reaction to target genes

21 January 2018

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Potential molecular mechanisms of oxidant-induced carcinogenesis

21 January 2018

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Persistent oxidative stress in cancer

21 January 2018

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Iron chelators in cancer chemotherapy

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Cyclin A in cell cycle control and cancer

21 January 2018

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Negative regulators of cyclin-dependent kinases and their roles in cancers

21 January 2018

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The Rb/E2F pathway and cancer

21 January 2018

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Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation

21 January 2018

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Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron

21 January 2018

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Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells

21 January 2018

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Iron chelators inhibit the growth and induce the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors.

21 January 2018

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Regulation of p53 downstream genes.

21 January 2018

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The role of p53 in human cancer

21 January 2018

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The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1.

21 January 2018

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Protein kinase C-mediated regulation of the cell cycle

21 January 2018

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Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.

21 January 2018

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

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Myc and Max function as a nucleoprotein complex

21 January 2018

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MYC oncogenes and human neoplastic disease

21 January 2018

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Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

21 January 2018

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Ribonucleotide reductases

21 January 2018

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Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins.

21 January 2018

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Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy

21 January 2018

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Hydroxyurea: new insights on an old drug

21 January 2018

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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

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The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

21 January 2018

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Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

21 January 2018

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The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes

21 January 2018

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Regulation of ferritin genes and protein

21 January 2018

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The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.

21 January 2018

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Interactions between doxorubicin and the human iron regulatory system.

21 January 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

21 January 2018

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Iron regulates nitric oxide synthase activity by controlling nuclear transcription

21 January 2018

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Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice

21 January 2018

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Failure to alter the course of acute myelogenous leukemia in the rat with subcutaneous deferoxamine

21 January 2018

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Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice

21 January 2018

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A phase II trial of deferoxamine in patients with hormone-refractory metastatic prostate cancer.

21 January 2018

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Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells

21 January 2018

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The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression

21 January 2018

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Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells

21 January 2018

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Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents

21 January 2018

1 reference

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Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation

21 January 2018

1 reference

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Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Desferrithiocin is an effective iron chelator in vivo and in vitro but ferrithiocin is toxic

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Desferrithiocin is a more potent antineoplastic agent than desferrioxamine.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Partition-variant desferrithiocin analogues: organ targeting and increased iron clearance

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

Activation of caspase pathways during iron chelator-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07357900500359976

Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

Lipophilic siderophores of Mycobacterium tuberculosis prevent cardiac reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900500359976

10.1080/07357900500359976

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

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