(Q36359660)

13 August 2017

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title

Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway (English)

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13 August 2017

2

Sergiusz Jozwiak

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13 August 2017

Maciej Jakub Lazarczyk

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4

object named as

Maciej Lazarczyk

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13 August 2017

Jaroslaw Jozwiak

1

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13 August 2017

Tomasz Grzela

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3

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13 August 2017

1 January 2005

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13 August 2017

NeuroMolecular Medicine

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13 August 2017

7

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13 August 2017

287-296

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13 August 2017

4

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https://scigraph.springernature.com/pub.10.1385/nmm:7:4:287

13 August 2017

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12 December 2020

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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12 December 2020

Identification and characterization of the tuberous sclerosis gene on chromosome 16

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12 December 2020

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

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12 December 2020

Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

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12 December 2020

Rheb binds and regulates the mTOR kinase

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12 December 2020

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

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12 December 2020

Characterisation of a novel TSC2 missense mutation in the GAP related domain associated with minimal clinical manifestations of tuberous sclerosis

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12 December 2020

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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12 December 2020

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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12 December 2020

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

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12 December 2020

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

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12 December 2020

The LKB1 tumor suppressor negatively regulates mTOR signaling

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12 December 2020

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

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12 December 2020

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

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12 December 2020

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

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12 December 2020

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein

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12 December 2020

Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions

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12 December 2020

The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation.

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12 December 2020

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

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12 December 2020

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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12 December 2020

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

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12 December 2020

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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12 December 2020

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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12 December 2020

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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12 December 2020

TSC2: filling the GAP in the mTOR signaling pathway

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12 December 2020

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

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12 December 2020

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

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12 December 2020

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

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12 December 2020

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

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12 December 2020

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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12 December 2020

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

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12 December 2020

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

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12 December 2020

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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12 December 2020

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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12 December 2020

Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.

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12 December 2020

Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex

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12 December 2020

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

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12 December 2020

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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12 December 2020

SKAR is a specific target of S6 kinase 1 in cell growth control

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12 December 2020

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

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12 December 2020

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

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12 December 2020

Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex

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12 December 2020

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

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12 December 2020

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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12 December 2020

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

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12 December 2020

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

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12 December 2020

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

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12 December 2020

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

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12 December 2020

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

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12 December 2020

Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

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12 December 2020

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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12 December 2020

Identifiers

DOI

10.1385/NMM:7:4:287

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Dimensions Publication ID

13 August 2017

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