(Q36372580)

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Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice (English)

1 reference

Europe PubMed Central

13 August 2017

0 references

insulin resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

James L Trevaskis

object named as

James L Trevaskis

1

0 references

author name string

Emily A Meyer

2

1 reference

Europe PubMed Central

13 August 2017

Jose E Galgani

3

1 reference

Europe PubMed Central

13 August 2017

Andrew A Butler

4

1 reference

Europe PubMed Central

13 August 2017

language of work or name

0 references

publication date

11 October 2007

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

149

1 reference

Europe PubMed Central

13 August 2017

1

1 reference

Europe PubMed Central

13 August 2017

174-184

1 reference

Europe PubMed Central

13 August 2017

Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons

1 reference

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30 September 2017

Inflammation and metabolic disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Genetics of Obesity in Humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Studies on the physiological functions of the melanocortin system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Distributed neural control of energy balance: contributions from hindbrain and hypothalamus

1 reference

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30 September 2017

Central nervous system control of food intake and body weight

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Leptin as a proinflammatory cytokine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Genetics of food intake and eating behavior phenotypes in humans

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

The human obesity gene map: the 2005 update

1 reference

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30 September 2017

Changes in gene expression foreshadow diet-induced obesity in genetically identical mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Role of melanocortin in the long-term regulation of energy balance: lessons from a seasonal model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Anatomy and regulation of the central melanocortin system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Induction of brain-region-specific forms of obesity by agouti.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

1 reference

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30 September 2017

Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

PTP1B regulates leptin signal transduction in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Obesity as a medical problem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Estrogen increases in vivo leptin production in rats and human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Relatively low plasma leptin concentrations precede weight gain in Pima Indians

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Role of leptin in the neuroendocrine response to fasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Effects of the obese gene product on body weight regulation in ob/ob mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Differential effects of melanocortin peptides on neural melanocortin receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

30 September 2017

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

28 June 2018

Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

28 June 2018

Melanocortin receptors in leptin effects.

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28 June 2018

Independent and additive effects of central POMC and leptin pathways on murine obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

28 June 2018

Overexpression of Agrt leads to obesity in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

28 June 2018

Diet-induced type II diabetes in C57BL/6J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

28 June 2018

Intake compensates for resting metabolic rate variation in female C57BL/6J mice fed high-fat diets.

1 reference

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21 September 2018

Gonadal hormones determine sensitivity to central leptin and insulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

21 September 2018

Divergence of melanocortin pathways in the control of food intake and energy expenditure.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

21 September 2018

Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity

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21 September 2018

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

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21 September 2018

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

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21 September 2018

Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.

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21 September 2018

Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice

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21 September 2018

Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

21 September 2018

Partial leptin deficiency and human adiposity.

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21 September 2018

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

21 September 2018

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

21 September 2018

Heterozygosity for aPOMC-Null Mutation and Increased Obesity Risk in Humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194611

5 December 2018

Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17932216

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17932216

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17932216

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/EN.2007-0868

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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