(Q36412675)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

3

1 reference

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23 March 2020

Valentin M Sluch

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Iain Fraser

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

author name string

Derek S Welsbie

1

1 reference

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23 March 2020

Katherine L Mitchell

2

1 reference

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23 March 2020

Zhiyong Yang

5

1 reference

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23 March 2020

Jessica Kim

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Eugen Buehler

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Amit Patel

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Scott E Martin

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Ping-Wu Zhang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Yan Ge

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Yukan Duan

12

1 reference

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23 March 2020

John Fuller

13

1 reference

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23 March 2020

Byung-Jin Kim

14

1 reference

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23 March 2020

Eman Hamed

15

1 reference

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23 March 2020

Xitiz Chamling

16

1 reference

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23 March 2020

Lei Lei

17

1 reference

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23 March 2020

Ze'ev A Ronai

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Cynthia A Berlinicke

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Donald J Zack

21

1 reference

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23 March 2020

language of work or name

English

0 references

publication date

1 June 2017

1 reference

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23 March 2020

1 reference

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23 March 2020

volume

94

1 reference

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23 March 2020

issue

6

1 reference

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23 March 2020

page(s)

1142-1154.e6

1 reference

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Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons

23 March 2020

cites work

1 reference

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Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling.

10 July 2018

1 reference

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Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line

10 July 2018

1 reference

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Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling

10 July 2018

1 reference

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Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.

10 July 2018

1 reference

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Pathological axonal death through a MAPK cascade that triggers a local energy deficit

10 July 2018

1 reference

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Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts

10 July 2018

1 reference

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CRISPR-Cas9 knockin mice for genome editing and cancer modeling

10 July 2018

1 reference

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ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates

10 July 2018

1 reference

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DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.

10 July 2018

1 reference

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Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila

10 July 2018

1 reference

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Sarm1-mediated axon degeneration requires both SAM and TIR interactions

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

siRNA off-target effects in genome-wide screens identify signaling pathway members

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

A novel high-content flow cytometric method for assessing the viability and damage of rat retinal ganglion cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Common seed analysis to identify off-target effects in siRNA screens

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Comprehensive analysis of kinase inhibitor selectivity

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

A conditional knockout resource for the genome-wide study of mouse gene function

10 July 2018

1 reference

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Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

JNK regulates FoxO-dependent autophagy in neurons

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

A role for ATF2 in regulating MITF and melanoma development

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model Is Sectorial and Involves Early Optic Nerve Axon Loss

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Host cell factors in HIV replication: meta-analysis of genome-wide studies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

A quantitative analysis of kinase inhibitor selectivity

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

The number of people with glaucoma worldwide in 2010 and 2020

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Expression profiling reveals off-target gene regulation by RNAi

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Identification and characterization of functional domains in a mixed lineage kinase LZK

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Genetic and environmental control of variation in retinal ganglion cell number in mice

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Persistent retrograde labeling of adult rat retinal ganglion cells with the carbocyanine dye diI.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

Minimizing the risk of reporting false positives in large-scale RNAi screens

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553555

10.1016/J.NEURON.2017.06.008

5 December 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28641113%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

28641113

1 reference