(Q36673015)

15 August 2017

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death (English)

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15 August 2017

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retinal ganglion cell

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29

Justin Hanes

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15 August 2017

16

Lucie Germain

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15 August 2017

8

Laszlo Hackler

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15 August 2017

32

Donald J Zack

1 reference

15 August 2017

23

Shannath L Merbs

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15 August 2017

Derek S Welsbie

1

1 reference

15 August 2017

Zhiyong Yang

2

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15 August 2017

Yan Ge

3

1 reference

15 August 2017

Katherine L Mitchell

4

1 reference

15 August 2017

Xinrong Zhou

5

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15 August 2017

Scott E Martin

6

1 reference

15 August 2017

Cynthia A Berlinicke

7

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15 August 2017

John Fuller

9

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15 August 2017

Jie Fu

10

1 reference

15 August 2017

Li-hui Cao

11

1 reference

15 August 2017

Bing Han

12

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15 August 2017

Douglas Auld

13

1 reference

15 August 2017

Tian Xue

14

1 reference

15 August 2017

Syu-ichi Hirai

15

1 reference

15 August 2017

Caroline Simard-Bisson

17

1 reference

15 August 2017

Richard Blouin

18

1 reference

15 August 2017

Judy V Nguyen

19

1 reference

15 August 2017

Chung-ha O Davis

20

1 reference

15 August 2017

Raymond A Enke

21

1 reference

15 August 2017

Sanford L Boye

22

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15 August 2017

Nicholas Marsh-Armstrong

24

1 reference

15 August 2017

William W Hauswirth

25

1 reference

15 August 2017

Aaron DiAntonio

26

1 reference

15 August 2017

Robert W Nickells

27

1 reference

15 August 2017

James Inglese

28

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15 August 2017

King-Wai Yau

30

1 reference

15 August 2017

Harry A Quigley

31

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15 August 2017

language of work or name

English

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publication date

19 February 2013

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Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

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15 August 2017

110

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15 August 2017

10

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15 August 2017

4045-4050

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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

High-throughput screening in primary neurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Axon degeneration: Molecular mechanisms of a self-destruction pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Comprehensive analysis of kinase inhibitor selectivity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Role of spleen tyrosine kinase inhibitors in the management of rheumatoid arthritis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Rho-kinase: important new therapeutic target in cardiovascular diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Neuroprotection in glaucoma: recent and future directions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Conserved genes act as modifiers of invertebrate SMN loss of function defects

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

ERK and cell death: ERK1/2 in neuronal death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Axon regeneration requires a conserved MAP kinase pathway.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

A quantitative analysis of kinase inhibitor selectivity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

The number of people with glaucoma worldwide in 2010 and 2020

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Protein kinases--the major drug targets of the twenty-first century?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Tissue transglutaminase triggers oligomerization and activation of dual leucine zipper-bearing kinase in calphostin C-treated cells to facilitate apoptosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Long-term gene-silencing effects of siRNA introduced by single-cell electroporation into postmitotic CNS neurons.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Early c-Jun N-terminal kinase-dependent phosphorylation of activating transcription factor-2 is associated with degeneration of retinal ganglion cells.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Transfer of small interfering RNA by single-cell electroporation in cerebellar cell cultures

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Highwire restrains synaptic growth by attenuating a MAP kinase signal.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593842

Photoreceptor degeneration in the RCS rat attenuates dendritic transport and axonal regeneration of ganglion cells

20 September 2018

1 reference

12 December 2020

Large porous particles for pulmonary drug delivery

1 reference

12 December 2020

Experimental induction of retinal ganglion cell death in adult mice

1 reference

12 December 2020

The JNK signal transduction pathway

1 reference

12 December 2020

Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1211284110

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15 August 2017

0 references

1 reference

15 August 2017

PubMed publication ID

23431148

1 reference