(Q37977169)

English

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

scientific article published on February 2012

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scholarly article

1 reference

Europe PubMed Central

26 August 2017

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies (English)

1 reference

Europe PubMed Central

26 August 2017

author name string

Clare Davies

1

1 reference

Europe PubMed Central

26 August 2017

Cathy Tournier

2

1 reference

Europe PubMed Central

26 August 2017

publication date

1 February 2012

1 reference

Europe PubMed Central

26 August 2017

Biochemical Society Transactions

1 reference

Europe PubMed Central

26 August 2017

40

1 reference

Europe PubMed Central

26 August 2017

1

1 reference

Europe PubMed Central

26 August 2017

85-89

1 reference

Europe PubMed Central

26 August 2017

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Mechanism of p38 MAP kinase activation in vivo.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Physiological roles of MKK4 and MKK7: insights from animal models

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The JIP family of MAPK scaffold proteins.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

A critical role of neural-specific JNK3 for ischemic apoptosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Apoptosis in neural development and disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Functional variant (-1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chinese population.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Role of mitogen-activated protein kinase kinase 4 in cancer

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1.

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Gene expression patterns in pancreatic tumors, cells and tissues

1 reference

https://api.crossref.org/works/10.1042%2FBST20110641

21 January 2018

Identifiers

10.1042/BST20110641

1 reference

Europe PubMed Central

26 August 2017

1 reference

Europe PubMed Central

26 August 2017

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