(Q36430899)

14 August 2017

Enhancement of bioreductive drug toxicity in murine tumours by inhibition of the activity of nitric oxide synthase (English)

1 reference

14 August 2017

6

I J Stratford

1 reference

14 August 2017

S A Butler

1

1 reference

14 August 2017

P J Wood

2

1 reference

14 August 2017

S Cole

3

1 reference

14 August 2017

C Williams

4

1 reference

14 August 2017

G E Adams

5

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 January 1997

1 reference

British Journal of Cancer

14 August 2017

1 reference

14 August 2017

76

1 reference

14 August 2017

4

1 reference

14 August 2017

438-444

1 reference

Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Manipulation and exploitation of the tumour environment for therapeutic benefit.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Nitric oxide synthase activity in human breast cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Potentiation of RSU-1069 tumour cytotoxicity by 5-hydroxytryptamine (5-HT).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Applicability of animal tumor data to cancer therapy in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Bioreductive drugs and the selective induction of tumour hypoxia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Nitric oxide: physiology, pathophysiology, and pharmacology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

In vivo evaluation of the radiosensitizing and cytotoxic properties of newly synthesized electron-affinic drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Expression of nitric oxide synthase in human central nervous system tumors.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

A new mouse tumor model system (RIF-1) for comparison of end-point studies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Pharmacokinetics and metabolism of the mixed-function hypoxic cell sensitizer prototype RSU 1069 in mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

Characterization of the factor in L-cell conditioned medium capable of stimulating colony formation by mouse marrow cells in culture

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2227976

An in vitro assay to measure the viability of KHT tumor cells not previously exposed to culture conditions

21 September 2018

1 reference

12 December 2020

The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gain

1 reference

12 December 2020

Blood flow and oxygenation of tumors in mice. II. Effects of vasodilator drugs

1 reference

12 December 2020

Cytotoxic Effects of the Hypoxic Cell Radiosensitizer Ro 7-0582 to Tumor Cells in Vivo

1 reference

12 December 2020

Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo

1 reference

12 December 2020

Hydralazine-induced tumor hypoxia: a potential target for cancer chemotherapy

1 reference

12 December 2020

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively ac

1 reference

12 December 2020

Induction of hypoxia in the KHT sarcoma by tumour necrosis factor and flavone acetic acid

1 reference

12 December 2020

Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin ?-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069)

1 reference

12 December 2020

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908)

1 reference

12 December 2020

Flavone acetic acid and 5,6-dimethylxanthenone-4-acetic acid: relationship between plasma nitrate elevation and the induction of tumour necrosis

1 reference

12 December 2020

Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro

1 reference

12 December 2020

Nitric oxide synthase activity in human gynecological cancer

1 reference

12 December 2020

The effect of vinca alkaloids on tumour blood flow

1 reference

12 December 2020

Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine

1 reference

12 December 2020

The influence of nitric oxide on tumour vascular tone

1 reference

12 December 2020

Anti-vascular approaches to solid tumour therapy: evaluation of vinblastine and flavone acetic acid

1 reference

12 December 2020

The cloning of normal ?Mast? cells in tissue culture

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1997.407

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

9275019

1 reference