(Q36453343)

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The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Europe PubMed Central

The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Gerard F. Hoyne

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

2

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Gerard F Hoyne

1

1 reference

Europe PubMed Central

14 August 2017

Christopher C Goodnow

2

1 reference

Europe PubMed Central

14 August 2017

publication date

1 April 2006

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Immunological Reviews

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

210

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19 January 2020

27-39

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16623762%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Cellular and genetic mechanisms of self tolerance and autoimmunity

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Regulation of thymocyte development: only the meek survive

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Negative selection--clearing out the bad apples from the T-cell repertoire

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

APECED: a monogenic autoimmune disease providing new clues to self-tolerance

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Positional cloning of the APECED gene

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Projection of an immunological self shadow within the thymus by the aire protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Aire regulates negative selection of organ-specific T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Signaling life and death in the thymus: timing is everything

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A role for Fas in negative selection of thymocytes in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Apoptosis, tolerance, and regulatory T cells--old wine, new wineskins

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Activation-induced cell death in T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

E3 ubiquitin ligases as T cell anergy factors.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Cbl-b regulates the CD28 dependence of T-cell activation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Egr-2 and Egr-3 are negative regulators of T cell activation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Sequence-based analysis of mutagenized mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A gene-driven approach to the identification of ENU mutants in the mouse

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Mouse ENU mutagenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

CD14 is required for MyD88-independent LPS signaling.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

CD36 is a sensor of diacylglycerides

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Illuminating autoimmune regulators through controlled variation of the mouse genome sequence

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Genome-wide ENU mutagenesis to reveal immune regulators

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00363.X

21 January 2018

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