(Q36462753)

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Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography

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Europe PubMed Central

PMC publication ID

14 August 2017

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

object named as

Stina Syvänen

8

0 references

object named as

Martin Bauer

3

0 references

Claudia Kuntner

object named as

Claudia Kuntner

2

0 references

object named as

Oliver Langer

7

0 references

author name string

Julia Müllauer

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Jens P Bankstahl

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Markus Müller

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Rob A Voskuyl

6

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Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

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publication date

16 October 2012

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Europe PubMed Central

PMC publication ID

14 August 2017

EJNMMI Research

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Europe PubMed Central

PMC publication ID

14 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

58

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

1 reference

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A pharmacokinetic PET study of NK₁ receptor occupancy

1 reference

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A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

1 reference

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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

1 reference

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30 September 2017

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

1 reference

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Carbon-11 labeled tracers for in vivo imaging P-glycoprotein function: kinetics, advantages and disadvantages.

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30 September 2017

Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.

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30 September 2017

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

1 reference

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30 September 2017

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

1 reference

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30 September 2017

Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications

1 reference

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Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

1 reference

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30 September 2017

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

1 reference

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30 September 2017

Refractory epilepsy: mechanisms and solutions

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Non-linear mixed effects modeling - from methodology and software development to driving implementation in drug development science

1 reference

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30 September 2017

Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations

1 reference

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Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

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Positron emission tomography compartmental models

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Graphical analysis of PET data applied to reversible and irreversible tracers

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A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier

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30 September 2017

Comparison of four basic models of indirect pharmacodynamic responses

1 reference

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Is the multidrug transporter a flippase?

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30 September 2017

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

1 reference

https://api.crossref.org/works/10.1186%2F2191-219X-2-58

21 January 2018

Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus

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21 January 2018

Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography

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Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography

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Modeling of brain D2 receptor occupancy-plasma concentration relationships with a novel antipsychotic, YKP1358, using serial PET scans in healthy volunteers

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Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

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https://api.crossref.org/works/10.1186%2F2191-219X-2-58

21 January 2018

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

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Estimate the time varying brain receptor occupancy in PET imaging experiments using non-linear fixed and mixed effect modeling approach.

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Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

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NONMEMory: a run management tool for NONMEM.

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Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

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The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study

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Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072492

12 December 2020

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Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

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https://pubmed.ncbi.nlm.nih.gov/23072492

12 December 2020

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Physiological parameters in laboratory animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23072492

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Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/2191-219X-2-58

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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