(Q36473472)

14 August 2017

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title

Transcriptional regulation of the human pregnane-X receptor (English)

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14 August 2017

Nick Plant

5

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author name string

G Gordon Gibson

1

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14 August 2017

Anna Phillips

2

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14 August 2017

Sihem Aouabdi

3

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14 August 2017

Kate Plant

4

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14 August 2017

language of work or name

English

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publication date

1 January 2006

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14 August 2017

published in

Drug Metabolism Reviews

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14 August 2017

volume

38

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14 August 2017

issue

1-2

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14 August 2017

page(s)

31-49

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Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

14 August 2017

cites work

1 reference

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Alternatively spliced isoforms of the human constitutive androstane receptor

21 January 2018

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Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

21 January 2018

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

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Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

21 January 2018

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Structure and function of the human nuclear xenobiotic receptor PXR.

21 January 2018

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Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

21 January 2018

1 reference

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Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

21 January 2018

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Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.

21 January 2018

1 reference

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Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

21 January 2018

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The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

21 January 2018

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Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

21 January 2018

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

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Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

21 January 2018

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Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

21 January 2018

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Receptor-dependent regulation of the CYP3A4 gene

21 January 2018

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Statins and transcriptional regulation: the FXR connection

21 January 2018

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Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5'-flanking region

21 January 2018

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Induction of drug metabolism: the role of nuclear receptors.

21 January 2018

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Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

21 January 2018

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Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms

21 January 2018

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Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

21 January 2018

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Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development

21 January 2018

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

21 January 2018

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Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

5' diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site

21 January 2018

1 reference

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PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

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Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis

21 January 2018

1 reference

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Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

21 January 2018

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

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Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery

21 January 2018

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Virtual gating and nuclear transport: the hole picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

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CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Nuclear receptors and drug disposition gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

TRANSFAC: a database on transcription factors and their DNA binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Insights from a three-dimensional model into ligand binding to constitutive active receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Interaction networks: coordinating responses to xenobiotic exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor alpha (hERalpha) LBD: quantitative structure-activity relationships within a series of CYP3A4 inducers where indu

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

A canonical structure for the ligand-binding domain of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569810

10.1080/03602530600569810

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference